Synthesis and preliminary antibacterial evaluation of Linezolid-like1,2,4-oxadiazole derivatives

Andrea Pace, Annalisa Guarcello, Antonio Palumbo Piccionello, Annalisa Guarcello, Andrea Pace, Paola Pierro, Cosimo Gianluca Fortuna, Clementina Cocuzza, Rosario Musumeci, Paola Pierro

Risultato della ricerca: Articlepeer review

48 Citazioni (Scopus)

Abstract

In the present study the synthesis of new Linezolid-like molecules has been achieved by substitutionof the oxazolidinone central heterocyclic moiety with a 1,2,4-oxadiazole ring. Two series of1,2,4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, weresynthesized and preliminarily tested for biological activity against some Gram-positive and Gramnegativebacteria using Linezolid and Ceftriaxone as reference drugs.
Lingua originaleEnglish
pagine (da-a)441-448
Numero di pagine8
RivistaEuropean Journal of Medicinal Chemistry
Volume50
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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