In the present study the synthesis of new Linezolid-like molecules has been achieved by substitutionof the oxazolidinone central heterocyclic moiety with a 1,2,4-oxadiazole ring. Two series of1,2,4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, weresynthesized and preliminarily tested for biological activity against some Gram-positive and Gramnegativebacteria using Linezolid and Ceftriaxone as reference drugs.
|Numero di pagine||8|
|Rivista||European Journal of Medicinal Chemistry|
|Stato di pubblicazione||Published - 2012|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry