SYNTHESIS AND PHOTOCHEMIOTHERAPEUTIC ACTIVITY OF THIOPYRANO[2,3-E]INDOL-2-ONES

Alessandra Montalbano, Patrizia Diana, Paola Barraja, Gaetano Dattolo, Antonino Lauria, Girolamo Cirrincione, Anna Maria Almerico, Silvia Disarò, Francesco Dall'Acqua, Giampietro Viola, Giuseppe Basso, Laura Sciabica

Risultato della ricerca: Article

12 Citazioni (Scopus)

Abstract

A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining newphotochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferativeeffect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogenresulted as the most interesting showing IC50 in the nanomolar range.
Lingua originaleEnglish
pagine (da-a)2291-2294
Numero di pagine4
RivistaBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume15
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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