SYNTHESIS AND EVALUATION OF CURCUMIN ANALOGUES AS NEURO-PROTECTIVE AGENTS FOR THE ALZHEIMER'S DISEASE

Risultato della ricerca: Other

Abstract

The Alzheimer's disease (AD) is the most common form of senile dementia.1 The most important role in AD is played by the aggregation process of beta-amyloid peptide (Aß), responsible for the cytotoxic effects.2 In this context, the purpose of this study was to synthesize new dicarbonyl compounds 1 structurally related to curcumin3, with anti-aggregation activity against Aß.Parallel studies involve the synthesis of heterocyclic-based curcumin-like molecules that are currently under investigation by means of in silico protocols in order to rationalize the ligand-biological target interactions.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2013

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Protective Agents
Curcumin
Agglomeration
Ligands
Molecules
peptide A
Amyloid

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@conference{737dd726d55a494ebe3462be0187c233,
title = "SYNTHESIS AND EVALUATION OF CURCUMIN ANALOGUES AS NEURO-PROTECTIVE AGENTS FOR THE ALZHEIMER'S DISEASE",
abstract = "The Alzheimer's disease (AD) is the most common form of senile dementia.1 The most important role in AD is played by the aggregation process of beta-amyloid peptide (A{\ss}), responsible for the cytotoxic effects.2 In this context, the purpose of this study was to synthesize new dicarbonyl compounds 1 structurally related to curcumin3, with anti-aggregation activity against A{\ss}.Parallel studies involve the synthesis of heterocyclic-based curcumin-like molecules that are currently under investigation by means of in silico protocols in order to rationalize the ligand-biological target interactions.",
keywords = "Alzheimer's Disease, amyloid peptide, curcumin, curcumin-like compounds",
author = "Silvestre Buscemi and Valentina Giacalone and Annamaria Martorana and Antonino Lauria and Angela Accardo and Almerico, {Anna Maria} and {Palumbo Piccionello}, Antonio",
year = "2013",
language = "English",

}

TY - CONF

T1 - SYNTHESIS AND EVALUATION OF CURCUMIN ANALOGUES AS NEURO-PROTECTIVE AGENTS FOR THE ALZHEIMER'S DISEASE

AU - Buscemi, Silvestre

AU - Giacalone, Valentina

AU - Martorana, Annamaria

AU - Lauria, Antonino

AU - Accardo, Angela

AU - Almerico, Anna Maria

AU - Palumbo Piccionello, Antonio

PY - 2013

Y1 - 2013

N2 - The Alzheimer's disease (AD) is the most common form of senile dementia.1 The most important role in AD is played by the aggregation process of beta-amyloid peptide (Aß), responsible for the cytotoxic effects.2 In this context, the purpose of this study was to synthesize new dicarbonyl compounds 1 structurally related to curcumin3, with anti-aggregation activity against Aß.Parallel studies involve the synthesis of heterocyclic-based curcumin-like molecules that are currently under investigation by means of in silico protocols in order to rationalize the ligand-biological target interactions.

AB - The Alzheimer's disease (AD) is the most common form of senile dementia.1 The most important role in AD is played by the aggregation process of beta-amyloid peptide (Aß), responsible for the cytotoxic effects.2 In this context, the purpose of this study was to synthesize new dicarbonyl compounds 1 structurally related to curcumin3, with anti-aggregation activity against Aß.Parallel studies involve the synthesis of heterocyclic-based curcumin-like molecules that are currently under investigation by means of in silico protocols in order to rationalize the ligand-biological target interactions.

KW - Alzheimer's Disease

KW - amyloid peptide

KW - curcumin

KW - curcumin-like compounds

UR - http://hdl.handle.net/10447/96982

M3 - Other

ER -