Abstract

Phenolic compound originated from one of the main class of secondary metabolites, as curcumin and its derivatives have been studied and their biological and pharmacological activities have been evaluated, too [1,2]. Unfortunately, curcumin exhibits poor bioavailability after oral or topic administration [3].Therefore a carefully designed carrier could significantly facilitate curcumin delivery and broaden the range of its possible pharmaceutical applications. Halloysite was found to be a viable and inexpensive nanoscale container for the encapsulation of biological active molecules [4].In this communication we report data about a new potential curcumin carrier based on positively charged functionalized halloysite nanotubes with triazolium salts (f-HNT). The interaction between curcumin and f-HNT was investigated by classical techniques as well as the release. Furthermore different cancer cell lines were used to evaluate the potential cytotoxic effect of the drug-carrier system.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2014

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Curcumin
Nanotubes
Salts
Drug Carriers
Metabolites
Encapsulation
Containers
Cells
clay
Derivatives
Molecules
Communication
Pharmaceutical Preparations

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@conference{8adea94e60af4d6982c01e4ef96a8a3a,
title = "SYNTHESIS AND CHARACTERIZATION OF POSITIVELY CHARGED FUNCTIONALIZED HALLOYSITE/CURCUMIN SYSTEMS AND EVALUATION OF THEIR ANTICANCER ACTIVITY",
abstract = "Phenolic compound originated from one of the main class of secondary metabolites, as curcumin and its derivatives have been studied and their biological and pharmacological activities have been evaluated, too [1,2]. Unfortunately, curcumin exhibits poor bioavailability after oral or topic administration [3].Therefore a carefully designed carrier could significantly facilitate curcumin delivery and broaden the range of its possible pharmaceutical applications. Halloysite was found to be a viable and inexpensive nanoscale container for the encapsulation of biological active molecules [4].In this communication we report data about a new potential curcumin carrier based on positively charged functionalized halloysite nanotubes with triazolium salts (f-HNT). The interaction between curcumin and f-HNT was investigated by classical techniques as well as the release. Furthermore different cancer cell lines were used to evaluate the potential cytotoxic effect of the drug-carrier system.",
keywords = "anticancer activity, curcumin, halloysite, triazolium salt",
author = "Marina Massaro and Giuseppe Lazzara and Renato Noto and Paola Poma and Serena Riela and Colletti, {Carmelo Giuseppe} and Carla Giordano and Stefana Milioto and Alessandra Bommarito",
year = "2014",
language = "English",

}

TY - CONF

T1 - SYNTHESIS AND CHARACTERIZATION OF POSITIVELY CHARGED FUNCTIONALIZED HALLOYSITE/CURCUMIN SYSTEMS AND EVALUATION OF THEIR ANTICANCER ACTIVITY

AU - Massaro, Marina

AU - Lazzara, Giuseppe

AU - Noto, Renato

AU - Poma, Paola

AU - Riela, Serena

AU - Colletti, Carmelo Giuseppe

AU - Giordano, Carla

AU - Milioto, Stefana

AU - Bommarito, Alessandra

PY - 2014

Y1 - 2014

N2 - Phenolic compound originated from one of the main class of secondary metabolites, as curcumin and its derivatives have been studied and their biological and pharmacological activities have been evaluated, too [1,2]. Unfortunately, curcumin exhibits poor bioavailability after oral or topic administration [3].Therefore a carefully designed carrier could significantly facilitate curcumin delivery and broaden the range of its possible pharmaceutical applications. Halloysite was found to be a viable and inexpensive nanoscale container for the encapsulation of biological active molecules [4].In this communication we report data about a new potential curcumin carrier based on positively charged functionalized halloysite nanotubes with triazolium salts (f-HNT). The interaction between curcumin and f-HNT was investigated by classical techniques as well as the release. Furthermore different cancer cell lines were used to evaluate the potential cytotoxic effect of the drug-carrier system.

AB - Phenolic compound originated from one of the main class of secondary metabolites, as curcumin and its derivatives have been studied and their biological and pharmacological activities have been evaluated, too [1,2]. Unfortunately, curcumin exhibits poor bioavailability after oral or topic administration [3].Therefore a carefully designed carrier could significantly facilitate curcumin delivery and broaden the range of its possible pharmaceutical applications. Halloysite was found to be a viable and inexpensive nanoscale container for the encapsulation of biological active molecules [4].In this communication we report data about a new potential curcumin carrier based on positively charged functionalized halloysite nanotubes with triazolium salts (f-HNT). The interaction between curcumin and f-HNT was investigated by classical techniques as well as the release. Furthermore different cancer cell lines were used to evaluate the potential cytotoxic effect of the drug-carrier system.

KW - anticancer activity

KW - curcumin

KW - halloysite

KW - triazolium salt

UR - http://hdl.handle.net/10447/97978

M3 - Other

ER -