Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis-1,8-naphthalimide Ligands

Alessio Terenzi, Alessio Terenzi, Bernhard K. Keppler, Wojciech Streciwilk, Pascal Prochnow, Federico Lo Nardo, Julia Elisabeth Bandow, Ingo Ott

Risultato della ricerca: Articlepeer review

10 Citazioni (Scopus)

Abstract

Organometallic N-heterocyclic carbene (NHC) complexes with intercalating bis-naphthalimide ligands were prepared and evaluated biologically. Cytotoxic effects against tumor cells or bacteria were strongly ligand dependent with minor influence of the metal (Ag, Ru, Rh, Au) centers. Complex 8b with a rhodium(I) NHC moiety was studied in more detail for its DNA interacting properties in comparison to the metal free ligand. These studies showed a good DNA binding pattern with some preference for the telomeric quadruplex structure hTelo. Complex 8b was also shown to trigger additional coordinative binding to the DNA and therefore represents an useful tool compound with a mixed intercalative/coordinative DNA binding mode.
Lingua originaleEnglish
pagine (da-a)3104-3112
Numero di pagine9
RivistaEUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1600.1604???

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