SYNTHESIS AND ANTITUMOR ACTIVITY OF 2,5-BIS(3'-INDOLYL)-FURANS AND 3,5-BIS(3'-INDOLIY)-ISOXAZOLES, NORTOPSENTIN ANALOGUES

Paola Barraja, Anna Carbone, Patrizia Diana, Girolamo Cirrincione, Heinz-Herbert Fiebig, Gerhard Kelter, Gerhard Kelter

Risultato della ricerca: Articlepeer review

113 Citazioni (Scopus)

Abstract

A series of novel 2,5-bis(3′-indolyl)furans and 3,5-bis(3′-indolyl)isoxazoles were synthesized as antitumor agents. The antiproliferative activity was evaluated in vitro toward diverse human tumor cell lines. Initially 5 isoxazoles and 3 furan derivatives were tested against a panel of 10 human tumor cell lines and the most active derivatives 3c and 4a were selected to be evaluated in an extended panel of 29 cell lines. By exhibiting mean IC50 values of 17.4 μg/mL (3a) and 20.5 μg/mL (4c), in particular 4c showed a high level of tumor selectivity toward the 29 cell lines.
Lingua originaleEnglish
pagine (da-a)4524-4529
Numero di pagine6
RivistaBIOORGANIC & MEDICINAL CHEMISTRY
Volume18
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1313???
  • ???subjectarea.asjc.1300.1312???
  • ???subjectarea.asjc.3000.3003???
  • ???subjectarea.asjc.3000.3002???
  • ???subjectarea.asjc.1300.1308???
  • ???subjectarea.asjc.1600.1605???

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