Abstract

3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.
Lingua originaleEnglish
Pagine378-378
Numero di pagine1
Stato di pubblicazionePublished - 2014

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Cells
Caspase 2
Derivatives
Automatic teller machines
Histones
Apoptosis
DNA
Proteins

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@conference{6acde0c47c394c8fab3c29a284581bd1,
title = "Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives",
abstract = "3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.",
author = "Cusimano, {Maria Grazia} and Demetrio Raffa and Cascioferro, {Stella Maria} and Daniela Carlisi and Benedetta Maggio and Fabiana Plescia and Gabriella Cancemi and Raimondi, {Maria Valeria} and Giuseppe Daidone and Marianna Lauricella",
year = "2014",
language = "English",
pages = "378--378",

}

TY - CONF

T1 - Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives

AU - Cusimano, Maria Grazia

AU - Raffa, Demetrio

AU - Cascioferro, Stella Maria

AU - Carlisi, Daniela

AU - Maggio, Benedetta

AU - Plescia, Fabiana

AU - Cancemi, Gabriella

AU - Raimondi, Maria Valeria

AU - Daidone, Giuseppe

AU - Lauricella, Marianna

PY - 2014

Y1 - 2014

N2 - 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.

AB - 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.

UR - http://hdl.handle.net/10447/98586

M3 - Other

SP - 378

EP - 378

ER -