SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF TRIAZENOINDAZOLES AND TRIAZENOPYRAZOLES: A COMPARATIVE STUDY

Risultato della ricerca: Articlepeer review

52 Citazioni (Scopus)

Abstract

Several triazenoindazoles and triazenopyrazoles were prepared transforming the appropriate aminoindazoles and aminopyrazoles in the corresponding diazonium salts which were reacted with dimethylamine, diethylamine and pyrrolidine. All the triazenes were tested for their antiproliferative activity against K562, HL60, L1210 and MCF7 cell lines. The biological data showed that the benzocondensation plays a positive role on the antiproliferative activity. The (1)H-NMR spectra showed that the rotational barrier around the N(2)-N(3) bond in the triazene group can be influenced both by the position of this group in the indazole nucleus and by the substitution pattern in the benzene moiety.
Lingua originaleEnglish
pagine (da-a)219-224
Numero di pagine6
RivistaEuropean Journal of Medicinal Chemistry
Volume39
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Fingerprint Entra nei temi di ricerca di 'SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF TRIAZENOINDAZOLES AND TRIAZENOPYRAZOLES: A COMPARATIVE STUDY'. Insieme formano una fingerprint unica.

Cita questo