Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin

Girolamo Cirrincione, Virginia Spano', Paola Barraja, Anna Carbone, Patrizia Diana, Barbara Parrino, Virginia Spanò, Heinz-Herbert Fiebig, Barbara Parrino, Gerhard Kelter, Anna Carbone, Paola Barraja, Girolamo Cirrincione, Patrizia Diana, Armin Maier, Gerhard Kelter

Risultato della ricerca: Articlepeer review

64 Citazioni (Scopus)

Abstract

2,5-bis(3′-Indolyl)pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good overall yields. Derivatives 1a and 1b exhibited concentration-dependent antitumor activity towards a panel of 42 human tumor cell lines with mean IC50 values of 1.54 μM and 0.67 μM, respectively. Investigating human tumor xenografts in an ex-vivo clonogenic assay revealed selective antitumor activity, whereas sensitive tumor models were scattered among various tumor histotypes.
Lingua originaleEnglish
pagine (da-a)643-654
Numero di pagine12
RivistaMarine Drugs
Volume11
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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