Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin

Paola Barraja, Barbara Parrino, Virginia Spano', Patrizia Diana, Girolamo Cirrincione, Anna Carbone, Virginia Spanò, Heinz-Herbert Fiebig, Barbara Parrino, Anna Carbone, Paola Barraja, Girolamo Cirrincione, Patrizia Diana, Armin Maier, Gerhard Kelter

Risultato della ricerca: Article

58 Citazioni (Scopus)

Abstract

2,5-bis(3′-Indolyl)pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good overall yields. Derivatives 1a and 1b exhibited concentration-dependent antitumor activity towards a panel of 42 human tumor cell lines with mean IC50 values of 1.54 μM and 0.67 μM, respectively. Investigating human tumor xenografts in an ex-vivo clonogenic assay revealed selective antitumor activity, whereas sensitive tumor models were scattered among various tumor histotypes.
Lingua originaleEnglish
pagine (da-a)643-654
Numero di pagine12
RivistaMarine Drugs
Volume11
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Fingerprint Entra nei temi di ricerca di 'Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin'. Insieme formano una fingerprint unica.

  • Cita questo

    Barraja, P., Parrino, B., Spano', V., Diana, P., Cirrincione, G., Carbone, A., Spanò, V., Fiebig, H-H., Parrino, B., Carbone, A., Barraja, P., Cirrincione, G., Diana, P., Maier, A., & Kelter, G. (2013). Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin. Marine Drugs, 11, 643-654.