Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles

Antonino Lauria; Paola Barraja; Anna Maria Almerico; Girolamo Cirrincione; Alessandra Montalbano; Gaetano Dattolo; Patrizia Diana; Girolamo Cirrincione

Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles

Antonino Lauria, Paola Barraja, Anna Maria Almerico, Girolamo Cirrincione, Alessandra Montalbano, Gaetano Dattolo, Patrizia Diana, Girolamo Cirrincione

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

9 Citazioni (Scopus)

Abstract

A series of [1,2,4]triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.

Lingua originale	English
pagine (da-a)	3775-3780
Numero di pagine	6
Rivista	Anticancer Research
Volume	24
Stato di pubblicazione	Published - 2004

All Science Journal Classification (ASJC) codes

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???subjectarea.asjc.1300.1306???

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title = "Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles",

abstract = "A series of [1,2,4]triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.",

author = "Antonino Lauria and Paola Barraja and Almerico, {Anna Maria} and Girolamo Cirrincione and Alessandra Montalbano and Gaetano Dattolo and Patrizia Diana and Girolamo Cirrincione",

year = "2004",

language = "English",

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pages = "3775--3780",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles

AU - Lauria, Antonino

AU - Barraja, Paola

AU - Almerico, Anna Maria

AU - Cirrincione, Girolamo

AU - Montalbano, Alessandra

AU - Dattolo, Gaetano

AU - Diana, Patrizia

AU - Cirrincione, Girolamo

PY - 2004

Y1 - 2004

N2 - A series of [1,2,4]triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.

AB - A series of [1,2,4]triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.

UR - http://hdl.handle.net/10447/32873

UR - http://ar.iiarjournals.org/content/24/6/3775.abstract

M3 - Article

VL - 24

SP - 3775

EP - 3780

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

ER -

Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles

Abstract

All Science Journal Classification (ASJC) codes

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