Eight derivatives of the new ring system [1,2,3,5]tetrazino[5,4-a]indole-4-one 7, were synthesised in good yields by reactionof 2-diazoindoles with alkyl or aryl isocyanates. Compounds 7 were screened at National Cancer Institute (NCI) for their activityagainst a panel of approximately 60 human tumour cell lines. Some of them showed antiproliferative activity having generallyGI50 in the micromolar range. The most sensitive cell lines were SF-295, SNB-75 and SF-539 of the CNS cancer sub-panel, SR of theleukaemia sub-panel, UACC-62 of the melanoma sub-panel and OVCAR-4 of the ovarian cancer sub-panel. 2004 Elsevier Ltd. All rights reserved.
|Numero di pagine||6|
|Rivista||BIOORGANIC & MEDICINAL CHEMISTRY|
|Stato di pubblicazione||Published - 2005|
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