TY - CONF
T1 - Synthesis and antioproliferative activity of new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine
AU - Raimondi, Maria Valeria
AU - Cusimano, Maria Grazia
AU - Maggio, Benedetta
AU - Raffa, Demetrio
AU - Cascioferro, Stella Maria
AU - Daidone, Giuseppe
AU - Plescia, Fabiana
AU - Cancemi, Gabriella
AU - Schillaci, Domenico
PY - 2012
Y1 - 2012
N2 - By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensulfonic acid, new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine were obtained. The new synthesized compounds were tested preliminarly at 10 microM against five human cancer cell lines showing a range of inhibition of 20-62% against the most susceptible cell lines K562 and HCT116.
AB - By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensulfonic acid, new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine were obtained. The new synthesized compounds were tested preliminarly at 10 microM against five human cancer cell lines showing a range of inhibition of 20-62% against the most susceptible cell lines K562 and HCT116.
UR - http://hdl.handle.net/10447/78181
M3 - Other
SP - 102
EP - 102
ER -