Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones.

Giuseppe Daidone; Benedetta Maggio; Demetrio Raffa; Fabiana Plescia; Stella Maria Cascioferro; Domenico Schillaci

Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones.

Giuseppe Daidone, Benedetta Maggio, Demetrio Raffa, Fabiana Plescia, Stella Maria Cascioferro, Domenico Schillaci

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

19 Citazioni (Scopus)

Abstract

3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a–l and 9a,c–e,h–l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a,c–e,h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.

Lingua originale	English
pagine (da-a)	451-455
Numero di pagine	5
Rivista	IL FARMACO
Volume	59
Stato di pubblicazione	Published - 2004

All Science Journal Classification (ASJC) codes

Pharmaceutical Science
Drug Discovery

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title = "Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones.",

abstract = "3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a–l and 9a,c–e,h–l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a,c–e,h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.",

author = "Giuseppe Daidone and Benedetta Maggio and Demetrio Raffa and Fabiana Plescia and Cascioferro, {Stella Maria} and Domenico Schillaci",

year = "2004",

language = "English",

volume = "59",

pages = "451--455",

journal = "Farmaco",

issn = "0014-827X",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones.

AU - Daidone, Giuseppe

AU - Maggio, Benedetta

AU - Raffa, Demetrio

AU - Plescia, Fabiana

AU - Cascioferro, Stella Maria

AU - Schillaci, Domenico

PY - 2004

Y1 - 2004

N2 - 3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a–l and 9a,c–e,h–l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a,c–e,h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.

AB - 3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a–l and 9a,c–e,h–l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a,c–e,h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.

UR - http://hdl.handle.net/10447/16725

M3 - Article

VL - 59

SP - 451

EP - 455

JO - Farmaco

JF - Farmaco

SN - 0014-827X

ER -