Abstract
3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a–l and 9a,c–e,h–l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a,c–e,h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.
Lingua originale | English |
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pagine (da-a) | 451-455 |
Numero di pagine | 5 |
Rivista | IL FARMACO |
Volume | 59 |
Stato di pubblicazione | Published - 2004 |
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery