SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF NEW 3-(1-PHENYL-3-METHYLPYRAZOL-5-YL)-2-STYRYLQUINAZOLIN-4(3H)-ONES

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Abstract

3-(1-Phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones 14a–q and 15a–q were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 12 and 13 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 14a–q and 15a–q were tested in vitro for their antileukemic activity against L1210 (murine leukemia), K562 (human chronic myelogenous leukemia) and HL60 (human leukemia) cell lines showing in some cases good activity.
Lingua originaleEnglish
pagine (da-a)215-221
Numero di pagine7
RivistaIL FARMACO
Volume59
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3000.3002???

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