SWITCHING FROM STATIN MONOTHERAPY TO EZETIMIBE/SIMVASTATIN OR ROSUVASTATIN MODIFIES THE RELATIONSHIPS BETWEEN APOLIPOPROTEIN B, LDL CHOLESTEROL, ANC NON-HDL CHOLETEROL IN PATIENTS AT HIGH RISK OF CORONARY DISEASE

Maurizio Averna, Luc Missault, Margus Viigimaa, Philippe Brudi, Arvind Shah, Qian Dong, Margus Viigimaa, Margus Viigimaa, Amy O. Johnson-Levonas, Helena Vaverkova, Michel Farnier, Maurizio Averna

Risultato della ricerca: Articlepeer review

3 Citazioni (Scopus)

Abstract

OBJECTIVE:To evaluate relationships between apolipoprotein B (Apo B), LDL cholesterol (LDL-C), and non-HDL-C in high-risk patients treated with lipid-lowering therapy.DESIGN AND METHODS:This post-hoc analysis calculated LDL-C and non-HDL-C levels corresponding to an Apo B of 0.9 g/L following treatment with 1) statin monotherapy (baseline) and 2) ezetimibe/simvastatin 10/20mg or rosuvastatin 10mg (study end). The percentages of patients reaching LDL-C, non-HDL-C, and Apo B targets were calculated at study end.RESULTS:After switching to ezetimibe/simvastatin or rosuvastatin, the LDL-C and non-HDL-C corresponding to Apo B=0.9 g/L were closer to the more aggressive LDL-C and non-HDL-C goals (1.81 and 2.59 mmol/L, respectively). Only slightly >50% of the patients who reached minimum recommended LDL-C or non-HDL-C at study end also had an Apo B level <0.9 g/L with both treatments.CONCLUSION:The use of Apo B for monitoring the efficacy of lipid-altering therapy would likely lead to more stringent criteria for lipid lowering.
Lingua originaleEnglish
pagine (da-a)627-634
Numero di pagine8
RivistaClinical Biochemistry
Volume44
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

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