Survival of patients with HCV cirrhosis and sustained virologic response is similar to the general population.

Vincenza Calvaruso, Vito Di Marco, Giuseppe Cabibbo, Antonio Craxi, Alessio Aghemo, Massimo Colombo, Vincenzo Boccaccio, Andrea Crosignani, Luigi Roffi, Massimo Iavarone, Patrick Maisonneuve, Savino Bruno, Mauro Viganò

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Abstract

Background & Aims: Life expectancy of patients with compensated hepatitis C virus (HCV) cirrhosis achieving sustained virologic response (SVR) is limited by liver events as compared tothe general population. Thus, survival benefit of SVR remains tobe measured.Methods: The study includes prospective surveillance data fromthree cohorts of Italian patients with compensated HCV cirrhosiswho achieved SVR on an interferon-based (IFN) regimen, compared to simultaneously observed non-SVR, untreated anddecompensated patients. Overall survival was calculated fromthe date of start of IFN to death. The number of deaths expectedduring the at-risk period was determined by applying age- andsex-specific mortality rates recorded in Italy for person-yearsadequate for the enrolment period. The standardized mortalityratio (SMR) determined the relative risk of death over that ofthe age and sex matched general population.Results: Overall, 28/181 patients followed-up for a medianperiod of 9.6 years (range 1–25 years) died. The 10 and 20-yearoverall survival rates for the whole series were 90.9% (95% CI,84.3–94.8) and 62.9% (95% CI, 45.9–75.9), respectively. The number of expected deaths in the corresponding age and sex matchedgeneral population was 28.1, corresponding to a SMR = 1.00 (95%CI, 0.72–1.35), with an SMR for non-SVR patients of 3.85 (95% CI,3.43–4.30), for untreated of 3.01 (95% CI, 2.64–3.42) and fordecompensated of 6.70 (95% CI, 5.39–8.22).Conclusions: Patients with compensated HCV cirrhosis achievingSVR by IFN obtain a main benefit levelling their survival curve tothat of the general population. Wider applicability of IFN-free regimens will possibly make this achievement more generalizable.
Lingua originaleEnglish
pagine (da-a)1217-1223
Numero di pagine7
RivistaJournal of Hepatology
Volume64
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Hepatology

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    Calvaruso, V., Di Marco, V., Cabibbo, G., Craxi, A., Aghemo, A., Colombo, M., Boccaccio, V., Crosignani, A., Roffi, L., Iavarone, M., Maisonneuve, P., Bruno, S., & Viganò, M. (2016). Survival of patients with HCV cirrhosis and sustained virologic response is similar to the general population. Journal of Hepatology, 64, 1217-1223.