Surveillance of human astrovirus circulation in Italy 2002-2005: emergence of lineage 2c strains

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Abstract

By screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95% of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5' end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.
Lingua originaleEnglish
pagine (da-a)97-101
Numero di pagine5
RivistaClinical Microbiology and Infection
Volume17
Stato di pubblicazionePublished - 2011

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Mamastrovirus
Hospitalized Child
Italy
Open Reading Frames
Diarrhea

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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title = "Surveillance of human astrovirus circulation in Italy 2002-2005: emergence of lineage 2c strains",
abstract = "By screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95{\%} of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5' end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.",
keywords = "Astrovirus, Italy, gastroenteritis, genotyping, sequence analysis",
author = "Platia, {Maria Angela} and Claudia Colomba and {De Grazia}, Simona and Giovanni Giammanco and Vito Martella",
year = "2011",
language = "English",
volume = "17",
pages = "97--101",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Surveillance of human astrovirus circulation in Italy 2002-2005: emergence of lineage 2c strains

AU - Platia, Maria Angela

AU - Colomba, Claudia

AU - De Grazia, Simona

AU - Giammanco, Giovanni

AU - Martella, Vito

PY - 2011

Y1 - 2011

N2 - By screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95% of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5' end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.

AB - By screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95% of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5' end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.

KW - Astrovirus

KW - Italy

KW - gastroenteritis

KW - genotyping

KW - sequence analysis

UR - http://hdl.handle.net/10447/52744

M3 - Article

VL - 17

SP - 97

EP - 101

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

ER -