Surgical sphincter saving approach and topical nifedipine for chronic anal fissure with hypertonic internal anal sphincter

Gaetano Giuseppe Di Vita, Sebastiano Bonventre, Beatrice D'Orazio, Girolamo Geraci, Guido Martorana, Fausto Famà, Giovanni Corbo, Gloria Maria Terranova

Risultato della ricerca: Articlepeer review


The role of augmented internal anal sphincter (IAS) tone in the genesis of posterior chronic anal fissure (CAPF) is still unknown. Lateral internal sphincterotomy is the most employed surgical procedure, nevertheless it is burdened by high risk post-operative anal incontinence. The aim of our study is to evaluate results of sphincter saving procedure with post-operative pharmacological sphincterotomy for patients affected by CAPF with IAS hypertonia. We enrolled 30 patients, undergone fissurectomy and anoplasty with V-Y cutaneous flap advancement; all patients received topical administration of nifedipine 0.3% and lidocaine 1.5% ointment-based therapy before and for 15 days after surgery. The primary goal was patient’s complete healing and the evaluation of incontinence and recurrence rate; the secondary goal included the evaluation of manometry parameters, symptom relief and complications related to nifedipine and lidocaine administration. All wounds healed within 40 days after surgery. We didn’t observe any “de novo” postoperative anal incontinence case. We reported 2 cases of recurrences, healed after conservative therapy. We didn’t report any local complications related to the administration of the ointment therapy; with whom all patients reported a good compliance. Fissurectomy and anoplasty with V-Y cutaneous advancement flap and topical administration of nifedipine and lidocaine, is an effective treatment for CAPF with IAS hypertonia.
Lingua originaleEnglish
pagine (da-a)585-594
Numero di pagine10
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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