Superficial venous thrombosis: Prevalence of common genetic risk factors and their role on spreading to deep veins

Minà, C.; Amato, C.; Grimaudo, S.

    Risultato della ricerca: Article

    41 Citazioni (Scopus)

    Abstract

    Introduction. Superficial venous thrombosis (SVT) has been considered for a long time a limited clinical condition with a low importance, but this approach has changed in recent years, when several studies demonstrated spreading to deep veins occurring from 7.3 to 44%, with high prevalence of pulmonary embolism . Materials and Methods. To evaluate the prevalence of genetic risk factors for VTE in patients suffering from SVT on both normal and varicose vein, and to evaluate their role on spreading to deep veins, we studied 107 consecutive outpatients with symptomatic SVT. Ultrasound examination was performed, and the presence of FV Leiden, Prothrombin G20210A mutation, MTHFR C677T mutation were researched. Results. In patients with SVT on healthy veins, the prevalence of thrombophilic conditions was consistent among all three mutations. In particularly, FV Leiden was more frequent in patients with venous progression to the deep system (60%) than in those without venous extension (23.6%). Similar results were found regarding FII G20210A and MTHFR C677T mutations in patients with (23.7% and 40%, respectively) or without thrombotic progression to the venous system (7.9% and 20%, respectively). Instead, in patients with SVT on varicose veins, the prevalence of FVL, FII and MTHFR mutations was low (6.7%, 4.4% and 6.7% respectively). However, even in these patients, the prevalence of FVL, FII and MTHFR C677T was higher in those with thrombus extension to the deep system (35.7%, 7.4% and 21.4% respectively) in comparison to those without. (6.7%, 4.4% and 6.7% respectively). Conclusions. Our data show the high prevalence of inherited thrombophilic states in patients with SVT on normal veins and their role in the progression to the deep vein system.
    Lingua originaleEnglish
    pagine (da-a)194-199
    Numero di pagine6
    RivistaThrombosis Research
    Volume123
    Stato di pubblicazionePublished - 2008

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    Venous Thrombosis
    Veins
    Mutation
    Varicose Veins
    Prothrombin
    Pulmonary Embolism
    Thrombosis
    Outpatients

    All Science Journal Classification (ASJC) codes

    • Hematology

    Cita questo

    Superficial venous thrombosis: Prevalence of common genetic risk factors and their role on spreading to deep veins. / Minà, C.; Amato, C.; Grimaudo, S.

    In: Thrombosis Research, Vol. 123, 2008, pag. 194-199.

    Risultato della ricerca: Article

    @article{a6a45cd0c5c64316acc7b66ab32db37b,
    title = "Superficial venous thrombosis: Prevalence of common genetic risk factors and their role on spreading to deep veins",
    abstract = "Introduction. Superficial venous thrombosis (SVT) has been considered for a long time a limited clinical condition with a low importance, but this approach has changed in recent years, when several studies demonstrated spreading to deep veins occurring from 7.3 to 44{\%}, with high prevalence of pulmonary embolism . Materials and Methods. To evaluate the prevalence of genetic risk factors for VTE in patients suffering from SVT on both normal and varicose vein, and to evaluate their role on spreading to deep veins, we studied 107 consecutive outpatients with symptomatic SVT. Ultrasound examination was performed, and the presence of FV Leiden, Prothrombin G20210A mutation, MTHFR C677T mutation were researched. Results. In patients with SVT on healthy veins, the prevalence of thrombophilic conditions was consistent among all three mutations. In particularly, FV Leiden was more frequent in patients with venous progression to the deep system (60{\%}) than in those without venous extension (23.6{\%}). Similar results were found regarding FII G20210A and MTHFR C677T mutations in patients with (23.7{\%} and 40{\%}, respectively) or without thrombotic progression to the venous system (7.9{\%} and 20{\%}, respectively). Instead, in patients with SVT on varicose veins, the prevalence of FVL, FII and MTHFR mutations was low (6.7{\%}, 4.4{\%} and 6.7{\%} respectively). However, even in these patients, the prevalence of FVL, FII and MTHFR C677T was higher in those with thrombus extension to the deep system (35.7{\%}, 7.4{\%} and 21.4{\%} respectively) in comparison to those without. (6.7{\%}, 4.4{\%} and 6.7{\%} respectively). Conclusions. Our data show the high prevalence of inherited thrombophilic states in patients with SVT on normal veins and their role in the progression to the deep vein system.",
    author = "{Min{\`a}, C.; Amato, C.; Grimaudo, S.} and Glauco Milio and Salvatore Novo and Sergio Siragusa and Egle Corrado",
    year = "2008",
    language = "English",
    volume = "123",
    pages = "194--199",
    journal = "Thrombosis Research",
    issn = "0049-3848",
    publisher = "Elsevier Limited",

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    TY - JOUR

    T1 - Superficial venous thrombosis: Prevalence of common genetic risk factors and their role on spreading to deep veins

    AU - Minà, C.; Amato, C.; Grimaudo, S.

    AU - Milio, Glauco

    AU - Novo, Salvatore

    AU - Siragusa, Sergio

    AU - Corrado, Egle

    PY - 2008

    Y1 - 2008

    N2 - Introduction. Superficial venous thrombosis (SVT) has been considered for a long time a limited clinical condition with a low importance, but this approach has changed in recent years, when several studies demonstrated spreading to deep veins occurring from 7.3 to 44%, with high prevalence of pulmonary embolism . Materials and Methods. To evaluate the prevalence of genetic risk factors for VTE in patients suffering from SVT on both normal and varicose vein, and to evaluate their role on spreading to deep veins, we studied 107 consecutive outpatients with symptomatic SVT. Ultrasound examination was performed, and the presence of FV Leiden, Prothrombin G20210A mutation, MTHFR C677T mutation were researched. Results. In patients with SVT on healthy veins, the prevalence of thrombophilic conditions was consistent among all three mutations. In particularly, FV Leiden was more frequent in patients with venous progression to the deep system (60%) than in those without venous extension (23.6%). Similar results were found regarding FII G20210A and MTHFR C677T mutations in patients with (23.7% and 40%, respectively) or without thrombotic progression to the venous system (7.9% and 20%, respectively). Instead, in patients with SVT on varicose veins, the prevalence of FVL, FII and MTHFR mutations was low (6.7%, 4.4% and 6.7% respectively). However, even in these patients, the prevalence of FVL, FII and MTHFR C677T was higher in those with thrombus extension to the deep system (35.7%, 7.4% and 21.4% respectively) in comparison to those without. (6.7%, 4.4% and 6.7% respectively). Conclusions. Our data show the high prevalence of inherited thrombophilic states in patients with SVT on normal veins and their role in the progression to the deep vein system.

    AB - Introduction. Superficial venous thrombosis (SVT) has been considered for a long time a limited clinical condition with a low importance, but this approach has changed in recent years, when several studies demonstrated spreading to deep veins occurring from 7.3 to 44%, with high prevalence of pulmonary embolism . Materials and Methods. To evaluate the prevalence of genetic risk factors for VTE in patients suffering from SVT on both normal and varicose vein, and to evaluate their role on spreading to deep veins, we studied 107 consecutive outpatients with symptomatic SVT. Ultrasound examination was performed, and the presence of FV Leiden, Prothrombin G20210A mutation, MTHFR C677T mutation were researched. Results. In patients with SVT on healthy veins, the prevalence of thrombophilic conditions was consistent among all three mutations. In particularly, FV Leiden was more frequent in patients with venous progression to the deep system (60%) than in those without venous extension (23.6%). Similar results were found regarding FII G20210A and MTHFR C677T mutations in patients with (23.7% and 40%, respectively) or without thrombotic progression to the venous system (7.9% and 20%, respectively). Instead, in patients with SVT on varicose veins, the prevalence of FVL, FII and MTHFR mutations was low (6.7%, 4.4% and 6.7% respectively). However, even in these patients, the prevalence of FVL, FII and MTHFR C677T was higher in those with thrombus extension to the deep system (35.7%, 7.4% and 21.4% respectively) in comparison to those without. (6.7%, 4.4% and 6.7% respectively). Conclusions. Our data show the high prevalence of inherited thrombophilic states in patients with SVT on normal veins and their role in the progression to the deep vein system.

    UR - http://hdl.handle.net/10447/5859

    M3 - Article

    VL - 123

    SP - 194

    EP - 199

    JO - Thrombosis Research

    JF - Thrombosis Research

    SN - 0049-3848

    ER -