Suggestive evidence for association of D2S2188 marker (2q31.1) with autism in 143 Sicilian (Italian) TRIO families

Fabio Canziani, Mario Giuseppe Mirisola, Gregorio Seidita, Valentino Romano, Giacomo De Leo, Francesco Calí, Salvatore Romano, Maurizio Elia, Pietro Schinocca, Filippo Cali', Giovanni Ayala, Rosalba D'Anna

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

We have screened 143 Sicilian (Italian) families with one autistic child to verify, by a linkage disequilibrium approach, the involvement of the 2q31.1 region in the cause of the disease in these families. Our study design includes the use of intrafamilial association to prevent a population stratification bias and ethnic homogeneity of the sample. The results of our analysis provided suggestive evidence of the occurrence of transmission disequilibrium between autism and the D2S2188 polymorphism in Sicilian TRIO families, a finding which provides further and independent support to the hypothesis of the existence of a susceptibility gene (or genes) for autism on chromosome 2q.
Lingua originaleEnglish
pagine (da-a)149-150
Numero di pagine2
RivistaPsychiatric Genetics
Volume15
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2716???
  • ???subjectarea.asjc.2700.2738???
  • ???subjectarea.asjc.2800.2803???

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