SUDDEN UNEXPLAINED JUVENILE DEATH AND THE ROLE OF MEDICOLEGALINVESTIGATION: UPDATE ON MOLECULAR AUTOPSY

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

In the past few years, contributions of molecular biology assays to the investigation of sudden juvenile death have permitted to clarify some of the pathogenetic aspects of sud-den arrhythmic death, opening the way to preventive action on victims’ relatives.We reviewed literature on the genetics of sudden juvenile death, and on molecular biol-ogy assays performed on autoptic samples.Biological investigation permits the detection of genetic mutations underlying the suscep-tibility to sudden cardiac death of individuals with rare inherited forms of arrhythmia (Long QT Syndrome, Brugada Syndrome, Lev’s disease etc.) through the analysis of criti-cal sequences codifying for ion channel subunits (HERG, KvLQT1, MinK, Mirp1, SCN5A, KCNQ1, KCNH2, KCNE1, KCNE2).The main objective of post-mortem investigation in sudden juvenile death is the detection of treatable monogenic inherited disorders, in order to prevent further deaths among the relatives of the deceased patient.
Lingua originaleEnglish
pagine (da-a)118-120
Numero di pagine3
RivistaEuroMediterranean Biomedical Journal
Volume25
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Entra nei temi di ricerca di 'SUDDEN UNEXPLAINED JUVENILE DEATH AND THE ROLE OF MEDICOLEGALINVESTIGATION: UPDATE ON MOLECULAR AUTOPSY'. Insieme formano una fingerprint unica.

Cita questo