Subthalamic deep brain stimulation improves time perception in Parkinson's disease

Massimiliano Oliveri, Carlo Caltagirone, Giacomo Koch, Antonella Peppe, Pietro Tiraboschi, Livia Brusa, Paolo Stanzione, Massimiliano Oliveri

Risultato della ricerca: Article

38 Citazioni (Scopus)

Abstract

Alterations in temporal estimation have been observed in Parkinson's disease (PD) and have been associated with dopaminergic dysfunction. To investigate whether deep brain stimulation might reverse these abnormalities in PD, patients treated with electrode implantation for subthalamic deep brain stimulation were required to reproduce time intervals in different experimental conditions (off deep brain stimulation/off therapy, on deep brain stimulation/off therapy, on therapy/off deep brain stimulation). Patients treated with deep brain stimulation in off deep brain stimulation/off therapy displayed the anomalous pattern of responses typically observed in PD. When subthalamic deep brain stimulation was turned on these abnormalities were significantly attenuated. Our findings reveal that subthalamic deep brain stimulation improves time perception in PD patients, supporting the critical role of basal ganglia in this cognitive function, probably mediated by facilitated thalamo-cortical projections to the prefrontal cortex.
Lingua originaleEnglish
pagine (da-a)1071-1073
Numero di pagine3
RivistaNeuroReport
Volume15(6)
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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