The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.
|Numero di pagine||3|
|Stato di pubblicazione||Published - 2006|
All Science Journal Classification (ASJC) codes
- Clinical Neurology
Bivona, G., Cevoli, Cortelli, P., Bivona, Montagna, Testa, Magnifico, Tonon, Pierangeli, Barbiroli, & Lodi (2006). Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy. Neurology, 66, 1264-1266.