TY - JOUR
T1 - Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells
AU - Grimaudo, Stefania
AU - Gebbia, Nicolo'
AU - Aiello, Stefania
AU - Abbadessa, Vincenzo
AU - Rossi, Matteo
AU - Gebbia, Nicola
AU - Grisolia, Giuseppina
AU - Giannini, Giuseppe
AU - Rossi, Marcello
AU - Crosta, Lucia
AU - Baruchello, Riccardo
AU - Rondanin, Riccardo
AU - Siniscalchi, Anna
AU - Simoni, Daniele
AU - Marino, Silvia
AU - Roberti, Marinella
AU - Cavallini, Sabrina
AU - Di Cristina, Antonietta
AU - Invidiata, Francesco
AU - Crosta, Lucia
PY - 2005
Y1 - 2005
N2 - New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
AB - New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
UR - http://hdl.handle.net/10447/16498
M3 - Article
VL - 48
SP - 4293
EP - 4299
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
ER -