Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells

Stefania Grimaudo, Nicolo' Gebbia, Vincenzo Abbadessa, Matteo Rossi, Stefania Aiello, Nicola Gebbia, Giuseppina Grisolia, Giuseppe Giannini, Marcello Rossi, Lucia Crosta, Riccardo Baruchello, Riccardo Rondanin, Anna Siniscalchi, Daniele Simoni, Silvia Marino, Marinella Roberti, Sabrina Cavallini, Antonietta Di Cristina, Francesco Invidiata, Lucia Crosta

Risultato della ricerca: Article

29 Citazioni (Scopus)

Abstract

New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
Lingua originaleEnglish
pagine (da-a)4293-4299
Numero di pagine7
RivistaJournal of Medicinal Chemistry
Volume48
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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    Grimaudo, S., Gebbia, N., Abbadessa, V., Rossi, M., Aiello, S., Gebbia, N., Grisolia, G., Giannini, G., Rossi, M., Crosta, L., Baruchello, R., Rondanin, R., Siniscalchi, A., Simoni, D., Marino, S., Roberti, M., Cavallini, S., Di Cristina, A., Invidiata, F., & Crosta, L. (2005). Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells. Journal of Medicinal Chemistry, 48, 4293-4299.