Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells

Stefania Grimaudo; Nicolo' Gebbia; Vincenzo Abbadessa; Matteo Rossi; Stefania Aiello; Nicola Gebbia; Giuseppina Grisolia; Giuseppe Giannini; Marcello Rossi; Lucia Crosta; Riccardo Baruchello; Riccardo Rondanin; Anna Siniscalchi; Daniele Simoni; Silvia Marino; Marinella Roberti; Sabrina Cavallini; Antonietta Di Cristina; Francesco Invidiata; Lucia Crosta

Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells

Stefania Grimaudo, Nicolo' Gebbia, Vincenzo Abbadessa, Matteo Rossi, Stefania Aiello, Nicola Gebbia, Giuseppina Grisolia, Giuseppe Giannini, Marcello Rossi, Lucia Crosta, Riccardo Baruchello, Riccardo Rondanin, Anna Siniscalchi, Daniele Simoni, Silvia Marino, Marinella Roberti, Sabrina Cavallini, Antonietta Di Cristina, Francesco Invidiata, Lucia Crosta

Risultato della ricerca: Article

29 Citazioni (Scopus)

Abstract

New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.

Lingua originale	English
pagine (da-a)	4293-4299
Numero di pagine	7
Rivista	Journal of Medicinal Chemistry
Volume	48
Stato di pubblicazione	Published - 2005

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

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Grimaudo, S., Gebbia, N., Abbadessa, V., Rossi, M., Aiello, S., Gebbia, N., Grisolia, G., Giannini, G., Rossi, M., Crosta, L., Baruchello, R., Rondanin, R., Siniscalchi, A., Simoni, D., Marino, S., Roberti, M., Cavallini, S., Di Cristina, A., Invidiata, F., & Crosta, L. (2005). Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells. Journal of Medicinal Chemistry, 48, 4293-4299.

Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells. / Grimaudo, Stefania ; Gebbia, Nicolo'; Abbadessa, Vincenzo ; Rossi, Matteo ; Aiello, Stefania; Gebbia, Nicola; Grisolia, Giuseppina; Giannini, Giuseppe; Rossi, Marcello; Crosta, Lucia; Baruchello, Riccardo; Rondanin, Riccardo; Siniscalchi, Anna; Simoni, Daniele; Marino, Silvia; Roberti, Marinella; Cavallini, Sabrina; Di Cristina, Antonietta; Invidiata, Francesco; Crosta, Lucia.

In: Journal of Medicinal Chemistry, Vol. 48, 2005, pag. 4293-4299.

Risultato della ricerca: Article

Grimaudo, S , Gebbia, N , Abbadessa, V , Rossi, M , Aiello, S, Gebbia, N, Grisolia, G, Giannini, G, Rossi, M, Crosta, L, Baruchello, R, Rondanin, R, Siniscalchi, A, Simoni, D, Marino, S, Roberti, M, Cavallini, S, Di Cristina, A, Invidiata, F & Crosta, L 2005, 'Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells', Journal of Medicinal Chemistry, vol. 48, pagg. 4293-4299.

Grimaudo, Stefania ; Gebbia, Nicolo' ; Abbadessa, Vincenzo ; Rossi, Matteo ; Aiello, Stefania ; Gebbia, Nicola ; Grisolia, Giuseppina ; Giannini, Giuseppe ; Rossi, Marcello ; Crosta, Lucia ; Baruchello, Riccardo ; Rondanin, Riccardo ; Siniscalchi, Anna ; Simoni, Daniele ; Marino, Silvia ; Roberti, Marinella ; Cavallini, Sabrina ; Di Cristina, Antonietta ; Invidiata, Francesco ; Crosta, Lucia. / Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells. In: Journal of Medicinal Chemistry. 2005 ; Vol. 48. pagg. 4293-4299.

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abstract = "New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.",

author = "Stefania Grimaudo and Nicolo' Gebbia and Vincenzo Abbadessa and Matteo Rossi and Stefania Aiello and Nicola Gebbia and Giuseppina Grisolia and Giuseppe Giannini and Marcello Rossi and Lucia Crosta and Riccardo Baruchello and Riccardo Rondanin and Anna Siniscalchi and Daniele Simoni and Silvia Marino and Marinella Roberti and Sabrina Cavallini and {Di Cristina}, Antonietta and Francesco Invidiata and Lucia Crosta",

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T1 - Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells

AU - Grimaudo, Stefania

AU - Gebbia, Nicolo'

AU - Abbadessa, Vincenzo

AU - Rossi, Matteo

AU - Aiello, Stefania

AU - Gebbia, Nicola

AU - Grisolia, Giuseppina

AU - Giannini, Giuseppe

AU - Rossi, Marcello

AU - Crosta, Lucia

AU - Baruchello, Riccardo

AU - Rondanin, Riccardo

AU - Siniscalchi, Anna

AU - Simoni, Daniele

AU - Marino, Silvia

AU - Roberti, Marinella

AU - Cavallini, Sabrina

AU - Di Cristina, Antonietta

AU - Invidiata, Francesco

AU - Crosta, Lucia

PY - 2005

Y1 - 2005

N2 - New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.

AB - New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.

UR - http://hdl.handle.net/10447/16498

M3 - Article

VL - 48

SP - 4293

EP - 4299

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

ER -