Studies on DNA interaction of organotin(IV) complexes of meso-tetra(4-sulfonatophenyl)porphine that show cellular activity

Claudia Pellerito, Tiziana Fiore, Sabriye Aydinoglu, Stefania Figuccia, Sonia Montanaro, Tarita Biver

Risultato della ricerca: Articlepeer review

7 Citazioni (Scopus)

Abstract

The interaction of the diorgano- and triorganotin(IV) derivatives of meso-tetra-(4-sulfonatophenyl)porphine (Me2Sn)2TPPS, (Bu2Sn)2TPPS, (Me3Sn)4TPPS and (Bu3Sn)4TPPS to natural DNA was analysed (together with free meso-tetra-(4-sulfonatophenyl)porphine (TPPS4−) for comparison purposes). Particular attention was paid to (Bu3Sn)4TPPS, a species that shows significant cellular action. Preliminary testswere done on the solution properties of the organotin(IV) compounds (pKA and possible self-aggregation). Spectrophotometric and spectrofluorometric experiments showed that all the investigated organotin(IV) derivatives strongly interact with DNA, the binding energy depending on the dye steric hindrance. In all cases experimental data concur in indicating that external binding mode prevails. Interestingly, fluorescence quenching and viscosity experiments show that the Bu-containing species, and in particular (Bu3Sn)4TPPS, are able to noticeably alter theDNA conformation.
Lingua originaleEnglish
pagine (da-a)311-317
Numero di pagine7
RivistaJournal of Inorganic Biochemistry
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Inorganic Chemistry

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