Strength and Latency of the HP-SAP Closed Loop Variability Interactions in Subjects Prone to Develop Postural Syncope

Luca Faes, Vlasta Bari, Gianluca Rossato, Davide Tonon, Beatrice Cairo, Emanuele Vaini, Beatrice De Maria, Alberto Porta

Risultato della ricerca: Conference contribution

1 Citazioni (Scopus)


The coupling and latency between heart period (HP) and systolic arterial pressure (SAP) variability can be investigated along the two arms of the HP-SAP closed loop, namely along the baroreflex feedback from SAP to HP, and along the feedforward pathway from HP to SAP. This study investigates the HP-SAP closed loop variability interactions through cross-correlation function (CCF). Coupling strength and delay between HP and SAP variability series were monitored in 13 subjects prone to develop orthostatic syncope (SYNC, 28±9 yrs, 5 males) and in 13 subjects with no history of postural syncope (noSYNC, age: 27±8 yrs, 5 males). Analysis was carried out at rest in supine position (REST) and during head-up tilt (TILT) at 60 degrees. The null hypothesis of HP-SAP uncoupling was tested through a surrogate analysis associating the HP series of a subject with a SAP sequence of a different one. Results showed that during TILT the coupling strength increased along the baroreflex and latency augmented along the mechanical feedforward pathway exclusively in noSYNC subjects. Finally, closed loop HP-SAP interactions were detected in about one third of subjects and the situation of full uncoupling was rarely found. CCF analysis was found to be a straightforward and easily applicable method to investigate HP-SAP control deserving a direct comparison with more sophisticated signal processing tools assessing causality.
Lingua originaleEnglish
Titolo della pubblicazione ospiteProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Numero di pagine4
Stato di pubblicazionePublished - 2019

Serie di pubblicazioni


All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1700.1711???
  • ???subjectarea.asjc.2200.2204???
  • ???subjectarea.asjc.1700.1707???
  • ???subjectarea.asjc.2700.2718???


Entra nei temi di ricerca di 'Strength and Latency of the HP-SAP Closed Loop Variability Interactions in Subjects Prone to Develop Postural Syncope'. Insieme formano una fingerprint unica.

Cita questo