Stilbene-based anticancer agents: Resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism.

Francesco Dieli, Enrico Aiello, Stefania Grimaudo, Stefania Aiello, Nicolo' Gebbia, Nicola Gebbia, Paolo Marchetti, Marco Eleopra, Antonietta Di Cristina, Lucia Crosta, Riccardo Baruchello, Stefania Grimaudo, Manlio Tolomeo, Daniele Simoni, Marinella Roberti, Antonietta Di Cristina, Francesco Invidiata, Lucia Crosta

Risultato della ricerca: Articlepeer review

73 Citazioni (Scopus)

Abstract

Several stilbenes, related to known resveratrol, have been synthesized and tested for their anticancer effect on HL60 leukemia cell line, taking particular care of the cell cycle analysis. The most potent compound was the known (Z)-3,4',5-trimethoxystilbene (6b) which was active as apoptotic agent at 0.24 microM. Differently from other stilbenes (including resveratrol) that induced a prevalent recruitment of cells in S phase of cell cycle, we found a peculiar behavior of 6b that caused a decrease of cells in all phases of cell cycle (G0-G1, S, and G2-M) and a proportional increase of apoptotic cells. The potent pro-apoptotic activity shown by compound 6b and its effects on cell cycle make this compound of great interest for further investigations.
Lingua originaleEnglish
pagine (da-a)3245-3248
Numero di pagine4
RivistaBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume16
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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