Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C

Daniela Cabibi, Giuseppe Cabibbo, Calogero Camma', Antonio Craxi, Rossella Alduino, Salvatore Petta, Vito Di Marco, Salvatore Petta, Giuseppe Cabibbo, Marcello Maida, Fabio Salvatore Macaluso, Calogero Cammà, Vito Di Marco, Antonio Craxì, Fabio Salvatore Macaluso

Risultato della ricerca: Article

47 Citazioni (Scopus)

Abstract

BACKGROUND &amp; AIMS: In Chronic Hepatitis C (CHC), the influence of steatosis on liver stiffness measurement (LSM) is still debated. We assessed the impact of steatosis and its ultrasonographical sign - bright liver echo pattern (BLEP) - on LSM values and on transient elastography (TE) accuracy for the diagnosis of liver fibrosis, in a cohort of consecutive patients with Genotype 1 (G1) CHC.METHODS: Patients (n=618) were assessed by clinical, ultrasonographic and histological (Scheuer score) features. TE was performed using the M probe.RESULTS: Male gender (p=0.04), steatosis as continuous variable (p<0.001), severity of necroinflammation (p=0.02) and stage of fibrosis (p<0.001) were associated with LSM by multivariate linear regression analysis. Among patients within the same fibrosis stages (F0-F2 and F3-F4; F0-F3 and F4), mean LSM values, expressed in kPa, were significantly higher in subjects with moderate-severe steatosis (⩾20% at liver biopsy) compared with those without, as well as in patients with BLEP on US compared with their counterpart. In subjects without severe fibrosis (F0-F2) and without cirrhosis (F0-F3), a higher rate of false-positive LSM results was observed in patients with steatosis ⩾20% compared with those without (F0-F2: 35.3% vs. 17.9%; F0-F3: 38.9% vs. 16.6%), and in patients with BLEP on US (F0-F2: 28.0% vs. 18.3%; F0-F3: 29.7% vs. 17.8%) compared with their counterpart.CONCLUSIONS: In patients with G1 CHC, the presence of moderate-severe steatosis, detected by histology or by US, should always be taken into account in order to avoid overestimations of liver fibrosis assessed by TE.
Lingua originaleEnglish
pagine (da-a)523-529
Numero di pagine7
RivistaJournal of Hepatology
Volume61
Stato di pubblicazionePublished - 2014

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Chronic Hepatitis C
Fibrosis
Genotype
Liver
Elasticity Imaging Techniques
Liver Cirrhosis
Fatty Liver
Linear Models
Histology
Regression Analysis
Biopsy

All Science Journal Classification (ASJC) codes

  • Hepatology

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Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C. / Cabibi, Daniela; Cabibbo, Giuseppe; Camma', Calogero; Craxi, Antonio; Alduino, Rossella; Petta, Salvatore; Di Marco, Vito; Petta, Salvatore; Cabibbo, Giuseppe; Maida, Marcello; Macaluso, Fabio Salvatore; Cammà, Calogero; Di Marco, Vito; Craxì, Antonio; Macaluso, Fabio Salvatore.

In: Journal of Hepatology, Vol. 61, 2014, pag. 523-529.

Risultato della ricerca: Article

Cabibi, Daniela ; Cabibbo, Giuseppe ; Camma', Calogero ; Craxi, Antonio ; Alduino, Rossella ; Petta, Salvatore ; Di Marco, Vito ; Petta, Salvatore ; Cabibbo, Giuseppe ; Maida, Marcello ; Macaluso, Fabio Salvatore ; Cammà, Calogero ; Di Marco, Vito ; Craxì, Antonio ; Macaluso, Fabio Salvatore. / Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C. In: Journal of Hepatology. 2014 ; Vol. 61. pagg. 523-529.
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title = "Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C",
abstract = "BACKGROUND & AIMS: In Chronic Hepatitis C (CHC), the influence of steatosis on liver stiffness measurement (LSM) is still debated. We assessed the impact of steatosis and its ultrasonographical sign - bright liver echo pattern (BLEP) - on LSM values and on transient elastography (TE) accuracy for the diagnosis of liver fibrosis, in a cohort of consecutive patients with Genotype 1 (G1) CHC.METHODS: Patients (n=618) were assessed by clinical, ultrasonographic and histological (Scheuer score) features. TE was performed using the M probe.RESULTS: Male gender (p=0.04), steatosis as continuous variable (p<0.001), severity of necroinflammation (p=0.02) and stage of fibrosis (p<0.001) were associated with LSM by multivariate linear regression analysis. Among patients within the same fibrosis stages (F0-F2 and F3-F4; F0-F3 and F4), mean LSM values, expressed in kPa, were significantly higher in subjects with moderate-severe steatosis (⩾20{\%} at liver biopsy) compared with those without, as well as in patients with BLEP on US compared with their counterpart. In subjects without severe fibrosis (F0-F2) and without cirrhosis (F0-F3), a higher rate of false-positive LSM results was observed in patients with steatosis ⩾20{\%} compared with those without (F0-F2: 35.3{\%} vs. 17.9{\%}; F0-F3: 38.9{\%} vs. 16.6{\%}), and in patients with BLEP on US (F0-F2: 28.0{\%} vs. 18.3{\%}; F0-F3: 29.7{\%} vs. 17.8{\%}) compared with their counterpart.CONCLUSIONS: In patients with G1 CHC, the presence of moderate-severe steatosis, detected by histology or by US, should always be taken into account in order to avoid overestimations of liver fibrosis assessed by TE.",
author = "Daniela Cabibi and Giuseppe Cabibbo and Calogero Camma' and Antonio Craxi and Rossella Alduino and Salvatore Petta and {Di Marco}, Vito and Salvatore Petta and Giuseppe Cabibbo and Marcello Maida and Macaluso, {Fabio Salvatore} and Calogero Camm{\`a} and {Di Marco}, Vito and Antonio Crax{\`i} and Macaluso, {Fabio Salvatore}",
year = "2014",
language = "English",
volume = "61",
pages = "523--529",
journal = "Journal of Hepatology",
issn = "0168-8278",
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}

TY - JOUR

T1 - Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C

AU - Cabibi, Daniela

AU - Cabibbo, Giuseppe

AU - Camma', Calogero

AU - Craxi, Antonio

AU - Alduino, Rossella

AU - Petta, Salvatore

AU - Di Marco, Vito

AU - Petta, Salvatore

AU - Cabibbo, Giuseppe

AU - Maida, Marcello

AU - Macaluso, Fabio Salvatore

AU - Cammà, Calogero

AU - Di Marco, Vito

AU - Craxì, Antonio

AU - Macaluso, Fabio Salvatore

PY - 2014

Y1 - 2014

N2 - BACKGROUND & AIMS: In Chronic Hepatitis C (CHC), the influence of steatosis on liver stiffness measurement (LSM) is still debated. We assessed the impact of steatosis and its ultrasonographical sign - bright liver echo pattern (BLEP) - on LSM values and on transient elastography (TE) accuracy for the diagnosis of liver fibrosis, in a cohort of consecutive patients with Genotype 1 (G1) CHC.METHODS: Patients (n=618) were assessed by clinical, ultrasonographic and histological (Scheuer score) features. TE was performed using the M probe.RESULTS: Male gender (p=0.04), steatosis as continuous variable (p<0.001), severity of necroinflammation (p=0.02) and stage of fibrosis (p<0.001) were associated with LSM by multivariate linear regression analysis. Among patients within the same fibrosis stages (F0-F2 and F3-F4; F0-F3 and F4), mean LSM values, expressed in kPa, were significantly higher in subjects with moderate-severe steatosis (⩾20% at liver biopsy) compared with those without, as well as in patients with BLEP on US compared with their counterpart. In subjects without severe fibrosis (F0-F2) and without cirrhosis (F0-F3), a higher rate of false-positive LSM results was observed in patients with steatosis ⩾20% compared with those without (F0-F2: 35.3% vs. 17.9%; F0-F3: 38.9% vs. 16.6%), and in patients with BLEP on US (F0-F2: 28.0% vs. 18.3%; F0-F3: 29.7% vs. 17.8%) compared with their counterpart.CONCLUSIONS: In patients with G1 CHC, the presence of moderate-severe steatosis, detected by histology or by US, should always be taken into account in order to avoid overestimations of liver fibrosis assessed by TE.

AB - BACKGROUND & AIMS: In Chronic Hepatitis C (CHC), the influence of steatosis on liver stiffness measurement (LSM) is still debated. We assessed the impact of steatosis and its ultrasonographical sign - bright liver echo pattern (BLEP) - on LSM values and on transient elastography (TE) accuracy for the diagnosis of liver fibrosis, in a cohort of consecutive patients with Genotype 1 (G1) CHC.METHODS: Patients (n=618) were assessed by clinical, ultrasonographic and histological (Scheuer score) features. TE was performed using the M probe.RESULTS: Male gender (p=0.04), steatosis as continuous variable (p<0.001), severity of necroinflammation (p=0.02) and stage of fibrosis (p<0.001) were associated with LSM by multivariate linear regression analysis. Among patients within the same fibrosis stages (F0-F2 and F3-F4; F0-F3 and F4), mean LSM values, expressed in kPa, were significantly higher in subjects with moderate-severe steatosis (⩾20% at liver biopsy) compared with those without, as well as in patients with BLEP on US compared with their counterpart. In subjects without severe fibrosis (F0-F2) and without cirrhosis (F0-F3), a higher rate of false-positive LSM results was observed in patients with steatosis ⩾20% compared with those without (F0-F2: 35.3% vs. 17.9%; F0-F3: 38.9% vs. 16.6%), and in patients with BLEP on US (F0-F2: 28.0% vs. 18.3%; F0-F3: 29.7% vs. 17.8%) compared with their counterpart.CONCLUSIONS: In patients with G1 CHC, the presence of moderate-severe steatosis, detected by histology or by US, should always be taken into account in order to avoid overestimations of liver fibrosis assessed by TE.

UR - http://hdl.handle.net/10447/97936

M3 - Article

VL - 61

SP - 523

EP - 529

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

ER -