Stabilizing versus destabilizing the microtubules: A double-edge sword for an effective cancer treatment option?

Giuseppe Cicero, Francesco Passiglia, Viviana Bazan, Daniela Massihnia, Valentina Calo', Marta Castiglia, Daniele Fanale, Giuseppe Bronte, Nadia Barraco, Francesca Toia, Alessandro Perez, Antonina Cangemi, Angela Listi', Florinda Di Piazza, Lavinia Insalaco, Francesca Toia, Marta Castiglia, Francesco Passiglia, Maria Teresa Catarella, Angela ListìRossella Maragliano, Antonina Cangemi, Nadia Barraco, Daniela Massihnia, Alessandro Perez, Giuseppe Cicero, Daniele Fanale, Viviana Bazan, Valentina Calò, Giuseppe Bronte, Florinda Di Piazza, Lavinia Insalaco, Maria Teresa Catarella

Risultato della ricerca: Articlepeer review

86 Citazioni (Scopus)


Microtubules are dynamic and structural cellular components involved in several cell functions, including cell shape, motility, and intracellular trafficking. In proliferating cells, they are essential components in the division process through the formation of the mitotic spindle. As a result of these functions, tubulin and microtubules are targets for anticancer agents. Microtubule-targeting agents can be divided into two groups: microtubule-stabilizing, and microtubule-destabilizing agents. The former bind to the tubulin polymer and stabilize microtubules, while the latter bind to the tubulin dimers and destabilize microtubules. Alteration of tubulin-microtubule equilibrium determines the disruption of the mitotic spindle, halting the cell cycle at the metaphase-anaphase transition and, eventually, resulting in cell death. Clinical application of earlier microtubule inhibitors, however, unfortunately showed several limits, such as neurological and bone marrow toxicity and the emergence of drug-resistant tumor cells. Here we review several natural and synthetic microtubule-targeting agents, which showed antitumor activity and increased efficacy in comparison to traditional drugs in various preclinical and clinical studies. Cryptophycins, combretastatins, ombrabulin, soblidotin, D-24851, epothilones and discodermolide were used in clinical trials. Some of them showed antiangiogenic and antivascular activity and others showed the ability to overcome multidrug resistance, supporting their possible use in chemotherapy.
Lingua originaleEnglish
Numero di pagine19
RivistaAnalytical Cellular Pathology
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1313???
  • ???subjectarea.asjc.1300.1307???
  • ???subjectarea.asjc.1300.1306???


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