Purpose Solid dispersions (SDs) represent the most commonformulation technique used to increase the dissolution rate ofa drug. In this work, the three most common methods used toprepare SDs, namely spray-drying, solvent-casting and freezedrying,have been compared in order to investigate their effecton increasing drug dissolution rate.Methods Three formulation strategies were used to preparea polymer mixture of polyvinyl-alcohol (PVA) and maltodextrin(MDX) as SDs loaded with the following three modeldrugs, all of which possess a poor solubility: Olanzapine,Dexamethasone, and Triamcinolone acetonide. The SDsobtained were analysed and compared in terms of drug particlesize, drug-loading capacity, surface homogeneity, anddissolution profile enhancement. Physical-chemical characterisationwas conducted on pure drugs, as well as the formulationsmade, by way of thermal analysis and infraredspectroscopy.Result The polymers used were able to increase drug saturationsolubility. The formulation strategies affected the drugparticle size, with the solvent-casting method resulting inmorehomogenous particle size and distribution when compared tothe other methods. The greatest enhancement in the drugdissolution rate was seen for all the samples prepared usingthe solvent-casting method.Conclusion All of the methods used were able to increase thedissolution rate of the pure drugs alone, however, the solventcastingmethod produced SDs with a higher surface homogeneity,drug incorporation capability, and faster dissolutionprofile than the other techniques.
|Numero di pagine||11|
|Stato di pubblicazione||Published - 2020|
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmaceutical Science
- Organic Chemistry
- Pharmacology (medical)