Spectrum of liver lesions hyperintense on hepatobiliary phase: an approach by clinical setting

Giuseppe Brancatelli, Roberto Cannella, Federica Vernuccio, Federica Vernuccio, Ahmed Ba-Ssalamah, An Tang, Roberto Cannella, Domenico Salvatore Gagliano, Giuseppe Brancatelli, Domenico Salvatore Gagliano

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)


Hepatobiliary MRI contrast agents are increasingly being used for liver imaging. In clinical practice, most focal liver lesions do not uptake hepatobiliary contrast agents. Less commonly, hepatic lesions may show variable signal characteristics on hepatobiliary phase. This pictorial essay reviews a broad spectrum of benign and malignant focal hepatic observations that may show hyperintensity on hepatobiliary phase in various clinical settings. In non-cirrhotic patients, focal hepatic observations that show hyperintensity in the hepatobiliary phase are usually benign and typically include focal nodular hyperplasia. In patients with primary or secondary vascular disorders, focal nodular hyperplasia-like lesions arise as a local hyperplastic response to vascular alterations and tend to be iso- or hyperintense in the hepatobiliary phase. In oncologic patients, metastases and cholangiocarcinoma are hypointense lesions in the hepatobiliary phase; however, occasionally they may show a diffuse, central and inhomogeneous hepatobiliary paradoxical uptake with peripheral rim hypointensity. Post-chemotherapy focal nodular hyperplasia-like lesions may be tricky, and their typical hyperintense rim in the hepatobiliary phase is very helpful for the differential diagnosis with metastases. In cirrhotic patients, hepatocellular carcinoma may occasionally appear hyperintense on hepatobiliary phase.
Lingua originaleEnglish
pagine (da-a)8-
Numero di pagine8
RivistaInsights into Imaging
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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