Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a givenadministration. Models based on body anatomy and physiology can provide an accurate description of drugconcentrations reached in specific organs and tissues of mammals. This article proposes a model based onmammalian anatomy and physiology to predict the biodistribution in mice of sorafenib, an anti-cancer drug,with specific attention to the concentration reached in the liver, as that is the action site in case ofhepatocellular carcinoma treatment. The model reveals a close correspondence respect to experimentalconcentration data in the organism and also assesses with good fidelity the enterohepatic circulation, aphenomenon occurring at the liver-intestine level and that strongly characterizes sorafenib distribution.
|Numero di pagine||6|
|Rivista||CHEMICAL ENGINEERING TRANSACTIONS|
|Stato di pubblicazione||Published - 2015|
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