Sorafenib: from literature to clinical practice

Vito Di Marco, Fernando De Vita, Semela, Koskinas, Verslype, Toniutto

Risultato della ricerca: Article

53 Citazioni (Scopus)


Sorafenib is considered the standard systemic therapy for hepatocellular carcinoma (HCC), in patients with well-preserved liver function (Child-Pugh A class) and advanced-stage HCC (BCLC-C) or in patients with HCC progressing after locoregional therapies, with a high grade of recommendation. The approval of sorafenib for this indication was grounded on the efficacy and the safety results reported by two international randomized, controlled trials, the SHARP and the Asia-Pacific studies. In addition, the efficacy and the safety of sorafenib in clinical practice are addressed by several field-practice experiences, including the multinational GIDEON study and the SOFIA study. Finally, further research on sorafenib is ongoing to optimize the use of this molecule. This review aims to provide an overview of the most relevant clinical data on the efficacy and the safety of sorafenib in patients with HCC.
Lingua originaleEnglish
pagine (da-a)30-37
Numero di pagine8
RivistaAnnals of Oncology
Stato di pubblicazionePublished - 2013


All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cita questo

Di Marco, V., De Vita, F., Semela, Koskinas, Verslype, & Toniutto (2013). Sorafenib: from literature to clinical practice. Annals of Oncology, 24, 30-37.