Soluble CD40L and cardiovascular risk in asymptomatic low-grade carotid stenosis

Carlo Maria Barbagallo; Egle Corrado; Salvatore Novo; Giuseppina Novo; Angela Falco; Stefania Basili; Giovanni Davì; Rosalba Tantillo; Valentina Davi'

Soluble CD40L and cardiovascular risk in asymptomatic low-grade carotid stenosis

Carlo Maria Barbagallo, Egle Corrado, Salvatore Novo, Giuseppina Novo, Angela Falco, Stefania Basili, Giovanni Davì, Rosalba Tantillo, Valentina Davi'

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

53 Citazioni (Scopus)

Abstract

BACKGROUND AND PURPOSE:We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques.METHODS:Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8 years).RESULTS:ALCS patients had higher (P<0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels (P=0.003) independently predicted cardiovascular risk.CONCLUSIONS:High levels of sCD40L may predict the risk of CV events in ALCS.

Lingua originale	English
pagine (da-a)	673-675
Numero di pagine	3
Rivista	Stroke
Volume	36
Stato di pubblicazione	Published - 2005

All Science Journal Classification (ASJC) codes

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Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialised Nursing

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title = "Soluble CD40L and cardiovascular risk in asymptomatic low-grade carotid stenosis",

abstract = "BACKGROUND AND PURPOSE:We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques.METHODS:Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8 years).RESULTS:ALCS patients had higher (P<0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels (P=0.003) independently predicted cardiovascular risk.CONCLUSIONS:High levels of sCD40L may predict the risk of CV events in ALCS.",

keywords = "Soluble CD40L, Soluble CD40L",

author = "Barbagallo, {Carlo Maria} and Egle Corrado and Salvatore Novo and Giuseppina Novo and Angela Falco and Stefania Basili and Giovanni Dav{\`i} and Rosalba Tantillo and Valentina Davi'",

year = "2005",

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TY - JOUR

T1 - Soluble CD40L and cardiovascular risk in asymptomatic low-grade carotid stenosis

AU - Barbagallo, Carlo Maria

AU - Corrado, Egle

AU - Novo, Salvatore

AU - Novo, Giuseppina

AU - Falco, Angela

AU - Basili, Stefania

AU - Davì, Giovanni

AU - Tantillo, Rosalba

AU - Davi', Valentina

PY - 2005

Y1 - 2005

N2 - BACKGROUND AND PURPOSE:We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques.METHODS:Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8 years).RESULTS:ALCS patients had higher (P<0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels (P=0.003) independently predicted cardiovascular risk.CONCLUSIONS:High levels of sCD40L may predict the risk of CV events in ALCS.

AB - BACKGROUND AND PURPOSE:We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques.METHODS:Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8 years).RESULTS:ALCS patients had higher (P<0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels (P=0.003) independently predicted cardiovascular risk.CONCLUSIONS:High levels of sCD40L may predict the risk of CV events in ALCS.

KW - Soluble CD40L

UR - http://hdl.handle.net/10447/4631

M3 - Article

VL - 36

SP - 673

EP - 675

JO - Stroke

JF - Stroke

SN - 0039-2499

ER -