Solid variant of mammary "adenoid cystic carcinoma with basaloid features" merging with "small cell carcinoma"

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Abstract

We describe a rare case of a solid variant of a mammary adenoid cystic carcinoma with basaloid features (sbACC) and its coexistence with a "small cell" carcinoma (SCC), identified and confirmed by histological and immunohistochemical observations: the absence of glandular structures and PAS-positive globules, positivity for neuroendocrine markers (NSE, synaptophysin and chromogranin), and negativity for 34betaE12 and SMA actin were the aspects suggesting the presence of SCC. Furthermore, positivity for CD10 was found both in sbA CC and in SCC, supporting the hypothesis that the two components share the same histogenetic myoepithelial origin and represent an example of dedifferentiation along neuroendocrine phenotype lines occurring in a multipotential neoplastic stem line, already committed towards a myoepithelial phenotype. To our knowledge, this is the first reported c ase of a solid basaloid adenoid cystic carcinoma merging with an SCC carcinoma. Furthermore, it is the first study in which CD10 was used to investigate the histogenesis of the two neoplastic components. © 2005 Elsevier GmbH. All rights reserved.
Lingua originaleEnglish
pagine (da-a)705-711
Numero di pagine7
RivistaPathology Research and Practice
Volume201
Stato di pubblicazionePublished - 2005

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Adenoid Cystic Carcinoma
Small Cell Carcinoma
Breast
Chromogranins
Phenotype
Synaptophysin
Actins
Carcinoma

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology

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title = "Solid variant of mammary {"}adenoid cystic carcinoma with basaloid features{"} merging with {"}small cell carcinoma{"}",
abstract = "We describe a rare case of a solid variant of a mammary adenoid cystic carcinoma with basaloid features (sbACC) and its coexistence with a {"}small cell{"} carcinoma (SCC), identified and confirmed by histological and immunohistochemical observations: the absence of glandular structures and PAS-positive globules, positivity for neuroendocrine markers (NSE, synaptophysin and chromogranin), and negativity for 34betaE12 and SMA actin were the aspects suggesting the presence of SCC. Furthermore, positivity for CD10 was found both in sbA CC and in SCC, supporting the hypothesis that the two components share the same histogenetic myoepithelial origin and represent an example of dedifferentiation along neuroendocrine phenotype lines occurring in a multipotential neoplastic stem line, already committed towards a myoepithelial phenotype. To our knowledge, this is the first reported c ase of a solid basaloid adenoid cystic carcinoma merging with an SCC carcinoma. Furthermore, it is the first study in which CD10 was used to investigate the histogenesis of the two neoplastic components. {\^A}{\circledC} 2005 Elsevier GmbH. All rights reserved.",
author = "Elisabetta Barresi and Florena, {Ada Maria} and Vito Rodolico and Salvatore Vieni and Daniela Cabibi",
year = "2005",
language = "English",
volume = "201",
pages = "705--711",
journal = "Pathology Research and Practice",
issn = "0344-0338",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",

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TY - JOUR

T1 - Solid variant of mammary "adenoid cystic carcinoma with basaloid features" merging with "small cell carcinoma"

AU - Barresi, Elisabetta

AU - Florena, Ada Maria

AU - Rodolico, Vito

AU - Vieni, Salvatore

AU - Cabibi, Daniela

PY - 2005

Y1 - 2005

N2 - We describe a rare case of a solid variant of a mammary adenoid cystic carcinoma with basaloid features (sbACC) and its coexistence with a "small cell" carcinoma (SCC), identified and confirmed by histological and immunohistochemical observations: the absence of glandular structures and PAS-positive globules, positivity for neuroendocrine markers (NSE, synaptophysin and chromogranin), and negativity for 34betaE12 and SMA actin were the aspects suggesting the presence of SCC. Furthermore, positivity for CD10 was found both in sbA CC and in SCC, supporting the hypothesis that the two components share the same histogenetic myoepithelial origin and represent an example of dedifferentiation along neuroendocrine phenotype lines occurring in a multipotential neoplastic stem line, already committed towards a myoepithelial phenotype. To our knowledge, this is the first reported c ase of a solid basaloid adenoid cystic carcinoma merging with an SCC carcinoma. Furthermore, it is the first study in which CD10 was used to investigate the histogenesis of the two neoplastic components. © 2005 Elsevier GmbH. All rights reserved.

AB - We describe a rare case of a solid variant of a mammary adenoid cystic carcinoma with basaloid features (sbACC) and its coexistence with a "small cell" carcinoma (SCC), identified and confirmed by histological and immunohistochemical observations: the absence of glandular structures and PAS-positive globules, positivity for neuroendocrine markers (NSE, synaptophysin and chromogranin), and negativity for 34betaE12 and SMA actin were the aspects suggesting the presence of SCC. Furthermore, positivity for CD10 was found both in sbA CC and in SCC, supporting the hypothesis that the two components share the same histogenetic myoepithelial origin and represent an example of dedifferentiation along neuroendocrine phenotype lines occurring in a multipotential neoplastic stem line, already committed towards a myoepithelial phenotype. To our knowledge, this is the first reported c ase of a solid basaloid adenoid cystic carcinoma merging with an SCC carcinoma. Furthermore, it is the first study in which CD10 was used to investigate the histogenesis of the two neoplastic components. © 2005 Elsevier GmbH. All rights reserved.

UR - http://hdl.handle.net/10447/287157

UR - http://www.journals.elsevier.com/pathology-research-and-practice/

M3 - Article

VL - 201

SP - 705

EP - 711

JO - Pathology Research and Practice

JF - Pathology Research and Practice

SN - 0344-0338

ER -