Smoking as a cofactor for causation of chronic pancreatitis: a meta-analysis.

Pier Luigi Almasio, Edoardo Botteri, Angelo Andriulli, Patrick Maisonneuve, Generoso Uomo, Italo Vantini

Risultato della ricerca: Articlepeer review

97 Citazioni (Scopus)


OBJECTIVES: To assess the evidence for tobacco smoking as a risk factor for the causation of chronic pancreatitis.METHODS: We performed a meta-analysis with random-effects models to estimate pooled relative risks (RRs) of chronic pancreatitis for current, former, and ever smokers, in comparison to never smokers. We also performed dose-response, heterogeneity, publication bias, and sensitivity analyses.RESULTS: Ten case-control studies and 2 cohort studies that evaluated, overall, 1705 patients with chronic pancreatitis satisfied the inclusion criteria. When contrasted to never smokers, the pooled risk estimates for current smokers was 2.8 (95% confidence interval [CI], 1.8-4.2) overall and 2.5 (95% CI, 1.3-4.6) when data were adjusted for alcohol consumption. A dose-response effect of tobacco use on the risk was ascertained: the RR for subjects smoking less than 1 pack per day was 2.4 (95% CI, 0.9-6.6) and increased to 3.3 (95% CI, 1.4-7.9) in those smoking 1 or more packs per day. The risk diminished significantly after smoking cessation, as the RR estimate for former smokers dropped to a value of 1.4 (95% CI, 1.1-1.9).CONCLUSIONS: Tobacco smoking may enhance the risk of developing chronic pancreatitis. Recommendation for smoking cessation, besides alcohol abstinence, should be incorporated in the management of patients with chronic pancreatitis.
Lingua originaleEnglish
Numero di pagine6
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2724???
  • ???subjectarea.asjc.2700.2712???
  • ???subjectarea.asjc.2700.2721???
  • ???subjectarea.asjc.1300.1310???


Entra nei temi di ricerca di 'Smoking as a cofactor for causation of chronic pancreatitis: a meta-analysis.'. Insieme formano una fingerprint unica.

Cita questo