SLEEP IN CHILDREN WITH AUTISTIC SPECTRUM DISORDER: A QUESTIONNAIRE AND POLYSOMNOGRAPHIC STUDY.

Michele Roccella, Alessia Trovato, Mario G. Terzano, Elisabetta Verrillo, Silvia Miano, Arianna Smerieri, Oliviero Bruni, Maurizio Elia, Raffaele Ferri

Risultato della ricerca: Articlepeer review

117 Citazioni (Scopus)

Abstract

Objective: To evaluate sleep in children with autistic spectrum disorder (ASD) by means of sleep questionnaires and polysomnography;moreover, to analyze their cyclic alternating pattern (CAP).Methods: Thirty-one patients with ASD (28 males, 3 females, aged 3.7–19 years) and age-matched normal controls were included.ASD children were evaluated by a standard sleep questionnaire that consisted of 45 items in a Likert-type scale covering severalareas of sleep disorders and by overnight polysomnography in the sleep laboratory after one adaptation night.Results: The questionnaire results showed that parents of ASD children reported a high prevalence of disorders of initiating andmaintaining sleep, enuresis, repetitive behavior when falling asleep, and daytime sleepiness. Polysomnographically, ASD childrenshowed reduced time in bed, total sleep time, sleep period time and rapid eye movement (REM) latency. ASD subjects had aCAP rate during slow-wave sleep (SWS) lower than normal controls, together with a lower percentage of A1 subtypes.Conclusions: ASD children questionnaires showed a higher percentage of disorders of initiating and maintaining sleep than normalcontrols; this was not completely confirmed by sleep staging. CAP measures showed subtle alterations of NREM sleep which couldbe detected with an appropriate methodology of analysis. The reduction of A1 subtypes during SWS might play a role in the impairmentof cognitive functioning in these subjects.
Lingua originaleEnglish
pagine (da-a)64-70
Numero di pagine7
RivistaSleep Medicine
Volume9
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

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