Single intense prenatal stress reduce behavioural suppression in an operant conflict paradigm in the adult progeny. Influence of Metyrapone administration

Carla Cannizzaro, Giacoma Mantia, Fulvio Plescia, Antonella Maria Elisa Modafferi, Giovanna Noto, Marco La Barbera

Risultato della ricerca: Other

Abstract

Stressors presented during late prenatal period can have long-term effects on offspring behaviour (1). Indeed we showed that in the rat progeny a single immobilization procedure at gestational day 16 enhances spatial learning in a non-aversive, rewarded-facilitated learning task, the Can Test, and decreases anxiety-like behaviour in the elevated plus maze (2). In this study, we wanted to investigate: (i) the effects of a single prenatal immobilization-stress on the operant conflict task (OCT), an anxiety-related procedure, in which positively reinforced responses are suppressed by contingent punishment (3); (ii) the expression of mineralcorticoid and glucocorticoid receptors (MRs, GRs) in the hippocampus and hypothalamus under basal and shock-induced conditions; (iii) the influence of an acute manipulation of corticosterone levels with metyrapone on the OCT. Our results show that: prenatal stress enhances the number of the punished responses in the OCT (p<0.05); MRs are increased in the hippocampus of control rats (p<0, 05), while GRs are increased in the hypothalamus of prenatally stressed rats (p<0, 05), following electric shock-exposure; metyrapone administration (50mg/kg) diminished the number of the punished responses both in prenatally-stressed and in control rats (p<0, 05). These data confirm that a single prenatal stress induces in the progeny a greater ability to cope with conflict situations, probably due to the different distribution of glucocorticoid receptors in the rat brain. Metyrapone induces a higher sensitivity to the electric shock, in both rat groups, likely as a consequence of a reduction in corticosterone levels (4).1) Yang J. et al, Neurobiol Learn &amp; Mem 87 (2007) 257-2632) Cannizzaro C. et al, Behav Br Res 169 (2006) 128-136 3) Loiseau F. et al, Behav Pharmacol 14 (2003) 447-4554) Malgorzata L. et al, Behav Br Res 171 (2006) 189-198
Lingua originaleEnglish
Pagine113-113
Numero di pagine1
Stato di pubblicazionePublished - 2008

Fingerprint Entra nei temi di ricerca di 'Single intense prenatal stress reduce behavioural suppression in an operant conflict paradigm in the adult progeny. Influence of Metyrapone administration'. Insieme formano una fingerprint unica.

Cita questo