Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy

Giampaolo Barone, Carmen Carneiro, Begoña García, José Maria Leal, M. Carmen Blanco, David Buceta, José Neissa, Kyra J. E. Borgman, Blanca Domínguez, Shahana Huseyinova, Natalia Busto, Vanesa Porto, Erea Borrajo, José Blanco, Melike Lakadamyali, Maria F. Garcia-Parajo, Tomás García-Caballero, M. Arturo López-Quintela, José Rivas, Fernando Domínguez

Risultato della ricerca: Articlepeer review

9 Citazioni (Scopus)

Abstract

Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3-AQCs)—developed by an ad hoc method—augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3-AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3-AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tissues. As a result, CDDP coadministered with Ag3-AQCs more strongly reduces the tumor burden. Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is now provided.
Lingua originaleEnglish
pagine (da-a)e1801317-
Numero di pagine8
RivistaAdvanced Materials
Volume30
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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  • Mechanics of Materials
  • Mechanical Engineering

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