Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy

Giampaolo Barone; Carmen Carneiro; Begoña García; José Maria Leal; M. Carmen Blanco; David Buceta; José Neissa; Kyra J. E. Borgman; Blanca Domínguez; Shahana Huseyinova; Natalia Busto; Vanesa Porto; Erea Borrajo; José Blanco; Melike Lakadamyali; Maria F. Garcia-Parajo; Tomás García-Caballero; M. Arturo López-Quintela; José Rivas; Fernando Domínguez

Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy

Giampaolo Barone, Carmen Carneiro, Begoña García, José Maria Leal, M. Carmen Blanco, David Buceta, José Neissa, Kyra J. E. Borgman, Blanca Domínguez, Shahana Huseyinova, Natalia Busto, Vanesa Porto, Erea Borrajo, José Blanco, Melike Lakadamyali, Maria F. Garcia-Parajo, Tomás García-Caballero, M. Arturo López-Quintela, José Rivas, Fernando Domínguez

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

9 Citazioni (Scopus)

Abstract

Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3-AQCs)—developed by an ad hoc method—augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3-AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3-AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tissues. As a result, CDDP coadministered with Ag3-AQCs more strongly reduces the tumor burden. Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is now provided.

Lingua originale	English
pagine (da-a)	e1801317-
Numero di pagine	8
Rivista	Advanced Materials
Volume	30
Stato di pubblicazione	Published - 2018

All Science Journal Classification (ASJC) codes

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Mechanics of Materials
Mechanical Engineering

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Barone, G., Carneiro, C., García, B., Leal, J. M., Blanco, M. C., Buceta, D., Neissa, J., Borgman, K. J. E., Domínguez, B., Huseyinova, S., Busto, N., Porto, V., Borrajo, E., Blanco, J., Lakadamyali, M., Garcia-Parajo, M. F., García-Caballero, T., López-Quintela, M. A., Rivas, J., & Domínguez, F. (2018). Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy. Advanced Materials, 30, e1801317-.

Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy. / Barone, Giampaolo; Carneiro, Carmen; García, Begoña; Leal, José Maria; Blanco, M. Carmen; Buceta, David; Neissa, José; Borgman, Kyra J. E.; Domínguez, Blanca; Huseyinova, Shahana; Busto, Natalia; Porto, Vanesa; Borrajo, Erea; Blanco, José; Lakadamyali, Melike; Garcia-Parajo, Maria F.; García-Caballero, Tomás; López-Quintela, M. Arturo; Rivas, José; Domínguez, Fernando.

In: Advanced Materials, Vol. 30, 2018, pag. e1801317-.

Risultato della ricerca: Article › peer review

Barone, G, Carneiro, C, García, B, Leal, JM, Blanco, MC, Buceta, D, Neissa, J, Borgman, KJE, Domínguez, B, Huseyinova, S, Busto, N, Porto, V, Borrajo, E, Blanco, J, Lakadamyali, M, Garcia-Parajo, MF, García-Caballero, T, López-Quintela, MA, Rivas, J & Domínguez, F 2018, 'Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy', Advanced Materials, vol. 30, pagg. e1801317-.

Barone, Giampaolo ; Carneiro, Carmen ; García, Begoña ; Leal, José Maria ; Blanco, M. Carmen ; Buceta, David ; Neissa, José ; Borgman, Kyra J. E. ; Domínguez, Blanca ; Huseyinova, Shahana ; Busto, Natalia ; Porto, Vanesa ; Borrajo, Erea ; Blanco, José ; Lakadamyali, Melike ; Garcia-Parajo, Maria F. ; García-Caballero, Tomás ; López-Quintela, M. Arturo ; Rivas, José ; Domínguez, Fernando. / Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy. In: Advanced Materials. 2018 ; Vol. 30. pagg. e1801317-.

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abstract = "Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3-AQCs)—developed by an ad hoc method—augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3-AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3-AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tissues. As a result, CDDP coadministered with Ag3-AQCs more strongly reduces the tumor burden. Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is now provided.",

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AU - Barone, Giampaolo

AU - Carneiro, Carmen

AU - García, Begoña

AU - Leal, José Maria

AU - Blanco, M. Carmen

AU - Buceta, David

AU - Neissa, José

AU - Borgman, Kyra J. E.

AU - Domínguez, Blanca

AU - Huseyinova, Shahana

AU - Busto, Natalia

AU - Porto, Vanesa

AU - Borrajo, Erea

AU - Blanco, José

AU - Lakadamyali, Melike

AU - Garcia-Parajo, Maria F.

AU - García-Caballero, Tomás

AU - López-Quintela, M. Arturo

AU - Rivas, José

AU - Domínguez, Fernando

PY - 2018

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N2 - Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3-AQCs)—developed by an ad hoc method—augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3-AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3-AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tissues. As a result, CDDP coadministered with Ag3-AQCs more strongly reduces the tumor burden. Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is now provided.

AB - Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3-AQCs)—developed by an ad hoc method—augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3-AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3-AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tissues. As a result, CDDP coadministered with Ag3-AQCs more strongly reduces the tumor burden. Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is now provided.

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KW - Mechanics of Materials

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KW - cancer therapy

KW - chromatin accessibility

KW - silver clusters

KW - DNA-binding drugs

KW - Materials Science (all)

KW - Mechanical Engineering

KW - Mechanics of Materials

KW - atomic quantum clusters

KW - cancer therapy

KW - chromatin accessibility

KW - silver clusters

UR - http://hdl.handle.net/10447/338539

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