Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis

Antonella Marino Gammazza, Fabio Bucchieri, Daniele Tibullo, Claudia Paternostro, Federico Salamone, Andrea Mangiameli, Fabio Bucchieri, Fabio Galvano, Giovanni Li Volti, Elisabetta Bugianesi, Maurizio Parola

Risultato della ricerca: Articlepeer review

Abstract

Background: Nonalcoholic fatty liver disease is a chronic metabolic disorder with significant impact oncardiovascular and liver mortality.Aims: In this study, we examined the effects of silibinin on liver and myocardium injury in an experimentalmodel of nonalcoholic fatty liver disease.Methods: A four-week daily dose of silibinin (20 mg/kg i.p.) was administrated to db/db mice fed amethionine–choline deficient diet. Hepatic and myocardial histology, oxidative stress and inflammatorycytokines were evaluated.Results: Silibinin administration decreased HOMA-IR, serum ALT and markedly improved hepatic andmyocardial damage. Silibinin reduced isoprostanes, 8-deoxyguanosine and nitrites/nitrates in the liverand in the heart of db/db fed the methionine–choline deficient diet, whereas glutathione levels wererestored to lean mice levels in both tissues. Consistently, liver mitochondrial respiratory chain activity wassignificantly impaired in untreated mice and was completely restored in silibinin-treated animals. TNF- was increased whereas IL-6 was decreased both in the liver and heart of db/db fed methionine–cholinedeficient diet. Silibinin reversed heart TNF- and IL-6 expression to control mice levels. Indeed, liver JNKphosphorylation was reduced to control levels in treated animals.Conclusions: This study demonstrates a combined
Lingua originaleEnglish
Numero di pagine8
RivistaDigestive and Liver Disease
Volume44
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2715???

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