Significance of P16INK4A hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

Valentina Agnese, Loredana Bruno, Antonio Russo, Vincenza Morello, Gaetana Di Fede, Valentina Calo', Eugenio Fiorentino, Antonino Agrusa, Mario Latteri, Viviana Bazan, Giuseppe Cicero, Vito Rodolico, Nello Grassi, Maria Rosaria Valerio, Rosa Maria Tomasino, Fiorentino, Grassi, Eugenio Fiorentino, Colucci, LatteriAltavilla, Mario A. Latteri, Adele Crosta, Claudia Augello, Donatella Calcara, Federica Latteri

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)

Abstract

BACKGROUND: Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivation; its incidence is extremely variable according to the type of tumor involved. Our purpose was to analyze the hypermethylation of the p16 promoter in laryngeal squamous cell carcinomas (LSCC), salivary gland (SG) tumors and in colorectal cancer (CRC), to detect any possible association with the clinicopathological features and to determine the prognostic significance of the p16 gene in the tumors analyzed.PATIENTS AND METHODS: The hypermethylation of the p16 promoter was prospectively analyzed, by MSP, in a consecutive series of 64 locally advanced LSCC patients, in a consecutive series of 33 SG tumor patients and in a consecutive series of 66 sporadic CRC patients.RESULTS: Hypermethylation was observed in 9% of the LSCC cases, in all cases of SG cancer and in 21% of the CRC cases. No significant association was observed between p16 hypermethylation and clinicopathological variables in all the tissue samples analyzed. Moreover at univariate analysis p16 mutations were not independently related at disease relapse and death in LSCC and CRC.CONCLUSIONS: The results of this study suggest that the lack of p16 function could happen in advanced stage of SG tumors.
Lingua originaleEnglish
pagine (da-a)137-141
Numero di pagine5
RivistaAnnals of Oncology
Volume17
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

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