Signature of recent historical events in the European Y-chromosomal STR haplotype distribution

Elena Carra, Sascha Willuweit, Manfred Kayser, Chris Tyler-Smith, Rüdiger Lessig, Lutz Roewer, Peter De Knijff, Michael Krawczak, Peter J.P. Croucher, Mark A. Jobling, Tim T. Lu, Leonarda Buscemi

Risultato della ricerca: Articlepeer review

150 Citazioni (Scopus)


Previous studies of human Y-chromosomal single-nucleotide polymorphisms (Y-SNPs) established a link between the extant Y-SNP haplogroup distribution and the prehistoric demography of Europe. By contrast, our analysis of seven rapidly evolving Y-chromosomal short tandem repeat loci (Y-STRs) in over 12,700 samples from 91 different locations in Europe reveals a signature of more recent historic events, not previously detected by other genetic markers. Cluster analysis based upon molecular variance yields two clearly identifiable sub-clusters of Western and Eastern European Y-STR haplotypes, and a diverse transition zone in central Europe, where haplotype spectra change more rapidly with longitude than with latitude. This and other observed patterns of Y-STR similarity may plausibly be related to particular historical incidents, including, for example, the expansion of the Franconian and Ottoman Empires. We conclude that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history.
Lingua originaleEnglish
pagine (da-a)279-291
Numero di pagine13
RivistaHuman Genetics
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2716???


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