SHORT COURSE TREATMENT OF VISCERAL LEISHMANIASIS WITH LIPOSOMAL AMPHOTERICIN B (AmBisome)

Antonio Cascio, Giovanni Battista Gaeta, Di Caprio, Raffaele Pempinello, Pempinello, Maisto, Marina Gramiccia, Scotti, Luigi Gradoni, Lucio Di Martino, Bryceson, Cascio, Raffaella Giacchino, Elio Castagnola, Robert N. Davidson, Robert Wilkinson

Risultato della ricerca: Articlepeer review

160 Citazioni (Scopus)

Abstract

We evaluated liposomal amphotericin B (AmBisome; Vestar, San Dimas, CA) administered to 88 immunocompetent patients (56 children) with visceral leishmaniasis (VL) caused by Leishmania infantum. Thirteen patients received 4 mg/kg on days 1-5 and 10 (total dose, 24 mg/kg), and all were cured; 42 received 3 mg/kg on days 1-5 and 10 (18 mg/kg), and 41 were cured; 32 received 3 mg/kg on days 1-4 and 10 (15 mg/kg), and 29 were cured (amastigotes were not cleared from 1 child, and 2 relapsed). One adult was cured with a total dose of 12mg/kg. The four children who were not cured received 3 mg/kg for 10 days; none had further relapses. There were no significant adverse events. For VL due to L. infantum, we recommended a total dose of AmBisome of > or = 20 mg/kg, given in > or = 5 doses of 3-4 mg/kg over > or = 10 days.
Lingua originaleEnglish
pagine (da-a)938-943
Numero di pagine6
RivistaClinical Infectious Diseases
Volume22
Stato di pubblicazionePublished - 1996

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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