Abstract
| Lingua originale | English |
|---|---|
| Numero di pagine | 0 |
| Rivista | ATHEROSCLEROSIS |
| Stato di pubblicazione | Published - 2017 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cita questo
Severe reduction of blood lysosomal acid lipase activity in cryptogenic cirrhosis: A nationwide multicentre cohort study. / Averna, Maurizio; Raparelli, Valeria; Masotti, Michela; Polimeni, Licia; Napoleone, Laura; Tovoli, Francesco; Di Michele, Dario; Angelico, Mario; Corazza, Gino Roberto; Violi, Francesco; Pastori, Daniele; Ippolito, Antonio M.; Parlati, Lucia; Ferri, Flaminia; Baratta, Francesco; Ciacciarelli, Marco; Santopaolo, Francesco; Pujatti, Pietro Luigi; Bucci, Tommaso; D'Amico, Jessica; Croce, Giuseppe; Faedo, Alessandra; Pellone, Monica; Bolondi, Luigi; Pellone, Monica; Corradini, Stefano Ginanni; Davì, Giovanni; Colzi, Marina; Francioso, Simona; Andreozzi, Paola; Del Ben, Maria; Labbadia, Giancarlo; Tozzi, Giulia; Fracanzani, Anna Ludovica; Andriulli, Angelo; Fargion, Silvia; Basili, Stefania; Bergamaschi, Gaetano; Angelico, Francesco; Perticone, Francesco; Iuliano, Luigi; Persico, Marcello; Davì, Giovanni; Mischitelli, Monica.
In: ATHEROSCLEROSIS, 2017.Risultato della ricerca: Article
}
TY - JOUR
T1 - Severe reduction of blood lysosomal acid lipase activity in cryptogenic cirrhosis: A nationwide multicentre cohort study
AU - Averna, Maurizio
AU - Raparelli, Valeria
AU - Masotti, Michela
AU - Polimeni, Licia
AU - Napoleone, Laura
AU - Tovoli, Francesco
AU - Di Michele, Dario
AU - Angelico, Mario
AU - Corazza, Gino Roberto
AU - Violi, Francesco
AU - Pastori, Daniele
AU - Ippolito, Antonio M.
AU - Parlati, Lucia
AU - Ferri, Flaminia
AU - Baratta, Francesco
AU - Ciacciarelli, Marco
AU - Santopaolo, Francesco
AU - Pujatti, Pietro Luigi
AU - Bucci, Tommaso
AU - D'Amico, Jessica
AU - Croce, Giuseppe
AU - Faedo, Alessandra
AU - Pellone, Monica
AU - Bolondi, Luigi
AU - Pellone, Monica
AU - Corradini, Stefano Ginanni
AU - Davì, Giovanni
AU - Colzi, Marina
AU - Francioso, Simona
AU - Andreozzi, Paola
AU - Del Ben, Maria
AU - Labbadia, Giancarlo
AU - Tozzi, Giulia
AU - Fracanzani, Anna Ludovica
AU - Andriulli, Angelo
AU - Fargion, Silvia
AU - Basili, Stefania
AU - Bergamaschi, Gaetano
AU - Angelico, Francesco
AU - Perticone, Francesco
AU - Iuliano, Luigi
AU - Persico, Marcello
AU - Davì, Giovanni
AU - Mischitelli, Monica
PY - 2017
Y1 - 2017
N2 - Background and aims: Blood lysosomal acid lipase (LAL) is reduced in non-alcoholic steatohepatitis, which is the major cause of cryptogenic cirrhosis (CC); few data on LAL activity in CC do exist. We investigated LAL activity in a cohort of patients with liver cirrhosis. Methods: This is a multicentre cohort study including 274 patients with liver cirrhosis of different aetiology from 19 centres of Internal Medicine, Gastroenterology and Hepatology distributed throughout Italy. Blood LAL activity (nmol/spot/h) was measured with dried blood spot extracts using Lalistat 2. Results: Overall, 133 patients had CC, and 141 patients had cirrhosis by other causes (61 viral, 53 alcoholic, 20 alcoholic + viral, 7 autoimmune). Mean age was 64.2 ± 13.4 years, and 28.5% were women. Patients with CC were older compared to other aetiology-cirrhosis, with a lower Child-Turcotte-Pugh (CTP, p=0.003) and MELD (p=0.009) score, and a higher prevalence of cardio-metabolic risk factors and previous ischemic events. In the whole cohort, median LAL activity value was 0.58 nmol/spot/h, 0.49 and 0.65 in the groups of CC and known-aetiology cirrhosis, respectively (p=0.002). The difference remained significant after adjustment for white blood cells count (p=0.001). Multivariable linear regression analysis showed that CC (vs. known aetiology, Beta = -0.144, p=0.018), platelet count (Beta = 0.398, p < 0.001) and CTP score (Beta = -0.133, p=0.022) were associated with log-LAL activity. Similar results were found using MELD as covariate. Conclusions: We found a marked reduction of LAL activity in patients with cryptogenic cirrhosis compared to the other known aetiologies. A prospective study will clarify the role of LAL in chronic liver diseases.
AB - Background and aims: Blood lysosomal acid lipase (LAL) is reduced in non-alcoholic steatohepatitis, which is the major cause of cryptogenic cirrhosis (CC); few data on LAL activity in CC do exist. We investigated LAL activity in a cohort of patients with liver cirrhosis. Methods: This is a multicentre cohort study including 274 patients with liver cirrhosis of different aetiology from 19 centres of Internal Medicine, Gastroenterology and Hepatology distributed throughout Italy. Blood LAL activity (nmol/spot/h) was measured with dried blood spot extracts using Lalistat 2. Results: Overall, 133 patients had CC, and 141 patients had cirrhosis by other causes (61 viral, 53 alcoholic, 20 alcoholic + viral, 7 autoimmune). Mean age was 64.2 ± 13.4 years, and 28.5% were women. Patients with CC were older compared to other aetiology-cirrhosis, with a lower Child-Turcotte-Pugh (CTP, p=0.003) and MELD (p=0.009) score, and a higher prevalence of cardio-metabolic risk factors and previous ischemic events. In the whole cohort, median LAL activity value was 0.58 nmol/spot/h, 0.49 and 0.65 in the groups of CC and known-aetiology cirrhosis, respectively (p=0.002). The difference remained significant after adjustment for white blood cells count (p=0.001). Multivariable linear regression analysis showed that CC (vs. known aetiology, Beta = -0.144, p=0.018), platelet count (Beta = 0.398, p < 0.001) and CTP score (Beta = -0.133, p=0.022) were associated with log-LAL activity. Similar results were found using MELD as covariate. Conclusions: We found a marked reduction of LAL activity in patients with cryptogenic cirrhosis compared to the other known aetiologies. A prospective study will clarify the role of LAL in chronic liver diseases.
UR - http://hdl.handle.net/10447/232637
UR - http://www.elsevier.com/locate/atherosclerosis
M3 - Article
JO - ATHEROSCLEROSIS
JF - ATHEROSCLEROSIS
SN - 0021-9150
ER -