Serum VEGF and b-FGF profiles after tension-free or conventional hernioplasty.

Gaetano Giuseppe Di Vita, Matteo Arcara, Francesco Arcoleo, Enrico Cillari, Giuseppe Caruso, Rosalia Patti, Valentina Davi'

Risultato della ricerca: Articlepeer review

11 Citazioni (Scopus)


Angiogenesis is strongly influenced by vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF), whose production is also regulated by interferon (IFN)-gamma and interleukin (IL)-10. The aim of this study was to evaluate the modifications of serum VEGF, b-FGF, IFN-gamma and IL-10 levels in patients with inguinal hernia undergoing hernioplasty with the Lichtenstein technique (LH) using polypropylene mesh or with Bassini open conventional inguinal hernia repair (BH).MATERIALS AND METHODS:Randomly, 16 patients underwent BH, and 16 were treated with the LH technique using polypropylene mesh. Blood samples were collected 24 h prior to surgery and then 6, 24, 48 and 168 h postoperatively. The serum concentrations of VEGF, b-FGF, IFN-gamma and IL-10 were evaluated.RESULTS:In BH patients, a peak of VEGF synthesis at 6 h with a normalization of this parameter 24 h after surgery has been observed. In the same subjects, b-FGF synthesis increased after surgery reaching significant levels 48 h later. On the contrary, in LH patients, a decrease in the serum VEGF and b-FGF concentrations was detected after surgery and their increase afterwards. IL-10 was increased in both groups 6 h after operation and declined to preoperative levels 24 h afterwards. IFN-gamma enhanced in LH patients 6 h after surgery, whereas no modifications were detected in BH subjects.CONCLUSIONS:This preliminary study shows that VEGF and b-FGF modifications, associated with alterations of cytokine secretion, are detectable in human undergoing hernioplasty, and suggests that they could somehow influence in the wound-healing process.
Lingua originaleEnglish
pagine (da-a)528-533
Numero di pagine6
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2746???


Entra nei temi di ricerca di 'Serum VEGF and b-FGF profiles after tension-free or conventional hernioplasty.'. Insieme formano una fingerprint unica.

Cita questo