TY - JOUR
T1 - Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study
AU - Barbagallo, Carlo Maria
AU - Cirillo, Pietro
AU - Quarti-Trevano, Fosca
AU - Grassi, Guido
AU - Cirillo, Massimo
AU - Mallamaci, Francesca
AU - Maloberti, Alessandro
AU - Gesualdo, Loreto
AU - D'Elia, Lanfranco
AU - Rivasi, Giulia
AU - Salvetti, Massimo
AU - Desideri, Giovambattista
AU - Palatini, Paolo
AU - Masi, Stefano
AU - Bruno, Bernardino
AU - Lippa, Luciano
AU - Parati, Gianfranco
AU - Verdecchia, Paolo
AU - Iaccarino, Guido
AU - Viazzi, Francesca
AU - Bombelli, Michele
AU - Tikhonoff, Valérie
AU - Tocci, Giuliano
AU - Cicero, Arrigo F.G.
AU - Pontremoli, Roberto
AU - Nazzaro, Pietro
AU - Rattazzi, Marcello
AU - Muiesan, Maria Lorenza
AU - Virdis, Agostino
AU - Salvetti, Massimo
AU - Casiglia, Edoardo
AU - Giannattasio, Cristina
AU - Galletti, Ferruccio
AU - Mazza, Alberto
AU - Ungar, Andrea
AU - Volpe, Massimo
AU - Palatini, Paolo
AU - Verdecchia, Paolo
AU - Borghi, Claudio
AU - Ferri, Claudio
PY - 2020
Y1 - 2020
N2 - Objective: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men.Methods: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18-95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ± 66.9 months.Results: A total of 23 467 individuals were included in the analysis. Cut-off values of SUA able to discriminate MI status were identified by mean of receiver operating characteristic curves in the whole database (>5.70 mg/dl), in women (>5.26 mg/dl) and in men (>5.49 mg/dl). Multivariate Cox regression analyses adjusted for confounders (age, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol and use of diuretics) identified an independent association between SUA and fatal MI in the whole database (hazard ratio 1.381, 95% confidence intervals, 1.096-1.758, P = 0.006) and in women (hazard ratio 1.514, confidence intervals 1.105-2.075, P < 0.01), but not in men.Conclusion: The results of the current study confirm that SUA is an independent risk factor for fatal MI after adjusting for potential confounding variables, and demonstrate that a prognostic cut-off value associated to fatal MI can be identified at least in women.
AB - Objective: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men.Methods: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18-95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ± 66.9 months.Results: A total of 23 467 individuals were included in the analysis. Cut-off values of SUA able to discriminate MI status were identified by mean of receiver operating characteristic curves in the whole database (>5.70 mg/dl), in women (>5.26 mg/dl) and in men (>5.49 mg/dl). Multivariate Cox regression analyses adjusted for confounders (age, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol and use of diuretics) identified an independent association between SUA and fatal MI in the whole database (hazard ratio 1.381, 95% confidence intervals, 1.096-1.758, P = 0.006) and in women (hazard ratio 1.514, confidence intervals 1.105-2.075, P < 0.01), but not in men.Conclusion: The results of the current study confirm that SUA is an independent risk factor for fatal MI after adjusting for potential confounding variables, and demonstrate that a prognostic cut-off value associated to fatal MI can be identified at least in women.
UR - http://hdl.handle.net/10447/465262
M3 - Article
SN - 2167-1095
SP - 412
EP - 419
JO - JOURNAL OF HYPERTENSION
JF - JOURNAL OF HYPERTENSION
ER -