TY - JOUR
T1 - Serum leptin and interleukin-6 levels in pediatric patients with HIV
AU - Maggio, Maria Cristina
AU - Di Carlo, Paola
AU - Titone Lanza Di Scalea, Lucina
AU - Teresi, Saverio
AU - Guicciardino, null
AU - Maggio, Maria Cristina
AU - Liotta, Andrea
AU - Miraglia, Piermauro
PY - 2003
Y1 - 2003
N2 - Recent therapeutic approaches have improved the prognosis of children with HIV. Many new efforts could be involved in their quality of life and therefore could need additional diagnostic strategies. Leptin regulates pubertal development; furthermore a continuous immune stimulus, as in chronic infectious diseases, can enhance leptin's secretion by the action of cytokines such as interleukin (IL)-6. To clarify this role in patients infected with HIV, we assayed leptin and IL-6 and evaluated the influence of HIV severity on its secretion. IL-6 (380.5 ± 257.6 pg/ml; range: 22-900 pg/ml) showed a significant correlation with leptinemia, HIV-1 RNA, and viremia related to the stage of HIV disease. The difference in leptinemia from a control group (3 ± 3.2 ng/ml; range: 1-12 ng/ml in HIV patients; 6.72 ± 8 ng/ml in the controls did not reach statistical significance, nor did it correlate with pubertal stage, BMI, viremia, CD4 or antiretroviral therapy. There was a statistically significant correlation between leptinemia and the stage of the HIV disease, and with IL-6 level. We want to stress the role of immunological factors in enhancing leptin secretion.
AB - Recent therapeutic approaches have improved the prognosis of children with HIV. Many new efforts could be involved in their quality of life and therefore could need additional diagnostic strategies. Leptin regulates pubertal development; furthermore a continuous immune stimulus, as in chronic infectious diseases, can enhance leptin's secretion by the action of cytokines such as interleukin (IL)-6. To clarify this role in patients infected with HIV, we assayed leptin and IL-6 and evaluated the influence of HIV severity on its secretion. IL-6 (380.5 ± 257.6 pg/ml; range: 22-900 pg/ml) showed a significant correlation with leptinemia, HIV-1 RNA, and viremia related to the stage of HIV disease. The difference in leptinemia from a control group (3 ± 3.2 ng/ml; range: 1-12 ng/ml in HIV patients; 6.72 ± 8 ng/ml in the controls did not reach statistical significance, nor did it correlate with pubertal stage, BMI, viremia, CD4 or antiretroviral therapy. There was a statistically significant correlation between leptinemia and the stage of the HIV disease, and with IL-6 level. We want to stress the role of immunological factors in enhancing leptin secretion.
KW - Interleukin-6; Leptin; Pediatric HIV; Puberty; Anti-HIV Agents; CD4 Antigens; Child; Child
KW - Leptin; Reverse Transcriptase Polymerase Chain Reaction; Sexual Maturation
KW - Preschool; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; HIV-1; Humans; Infant; Interleukin-6; Leptin; Male; Receptors
KW - Interleukin-6; Leptin; Pediatric HIV; Puberty; Anti-HIV Agents; CD4 Antigens; Child; Child
KW - Leptin; Reverse Transcriptase Polymerase Chain Reaction; Sexual Maturation
KW - Preschool; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; HIV-1; Humans; Infant; Interleukin-6; Leptin; Male; Receptors
UR - http://hdl.handle.net/10447/423014
M3 - Article
VL - 16
SP - 179
EP - 183
JO - JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
JF - JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
SN - 0334-018X
ER -