Serum leptin and interleukin-6 levels in pediatric patients with HIV

Paola Di Carlo, Lucina Titone Lanza Di Scalea, Maria Cristina Maggio, Saverio Teresi, Guicciardino, Maria Cristina Maggio, Andrea Liotta, Piermauro Miraglia

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

Recent therapeutic approaches have improved the prognosis of children with HIV. Many new efforts could be involved in their quality of life and therefore could need additional diagnostic strategies. Leptin regulates pubertal development; furthermore a continuous immune stimulus, as in chronic infectious diseases, can enhance leptin's secretion by the action of cytokines such as interleukin (IL)-6. To clarify this role in patients infected with HIV, we assayed leptin and IL-6 and evaluated the influence of HIV severity on its secretion. IL-6 (380.5 ± 257.6 pg/ml; range: 22-900 pg/ml) showed a significant correlation with leptinemia, HIV-1 RNA, and viremia related to the stage of HIV disease. The difference in leptinemia from a control group (3 ± 3.2 ng/ml; range: 1-12 ng/ml in HIV patients; 6.72 ± 8 ng/ml in the controls did not reach statistical significance, nor did it correlate with pubertal stage, BMI, viremia, CD4 or antiretroviral therapy. There was a statistically significant correlation between leptinemia and the stage of the HIV disease, and with IL-6 level. We want to stress the role of immunological factors in enhancing leptin secretion.
Lingua originaleEnglish
pagine (da-a)179-183
Numero di pagine5
RivistaJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Volume16
Stato di pubblicazionePublished - 2003

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2735???
  • ???subjectarea.asjc.2700.2712???
  • ???subjectarea.asjc.1300.1310???

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