Serum dehydroepiandrosterone sulfate and incident depression in the elderly: The Pro.V.A. study

Nicola Veronese, Enzo Manzato, Francesco Bolzetta, Nicola Veronese, Marina De Rui, Elena Debora Toffanello, Egle Perissinotto, Sabina Zambon, Giuseppe Sergi, Giovannella Baggio, Maria Chiara Corti, Gaetano Crepaldi, Giorgio Sergi

Risultato della ricerca: Articlepeer review


Objective: Dehydroepiandrosterone sulfate (DHEAS) appears to have a protective effect against depression, but contrasting findings are available. Therefore, we investigated whether high serum DHEAS levels were associated with any protective effect on incident depression and incident severe depression in a representative group of elderly men and women. Methods: In a population-based cohort longitudinal study in the general community, 789 older participants without depression and cognitive impairment at the baseline were included, among 3,099 screened subjects. Serum DHEAS levels were determined based on blood samples; incident depression and severe depression were diagnosed by means of the Geriatric Depression Scale (GDS) and confirmed by geriatricians skilled in psychogeriatric medicine. Results: No baseline differences were found in GDS across age-and gender-specific tertiles of serum DHEAS. Over 4.4 years of follow-up, 137 new cases of depression were recorded. Of them, 35 among men and 64 in women were cases of incident severe depression. Cox's regression analysis, adjusted for potential confounders, revealed that higher DHEAS levels were associated with reduced risk of incident depression irrespective of gender (HR: 0.30; 95% CI: 0.09-0.96; Wald χ2 = 4.09; df = 1; p = 0.04; women: HR: 0.31; 95% CI: 0.14-0.69; Wald χ2 = 8.37; df = 1; p = 0.004) and of severe incident depression only in men (HR: 0.25; 95% CI: 0.06-0.99; Wald χ2 = 4.05; df = 1; p = 0.04). Conclusion: Higher serum DHEAS levels were found to be significantly protective for the onset of depression irrespective of gender, whereas only in men was this association found also for incident severe depression. © 2015 American Association for Geriatric Psychiatry.
Lingua originaleEnglish
pagine (da-a)863-871
Numero di pagine9
RivistaAmerican Journal of Geriatric Psychiatry
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2738???

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