Serum 25-hydroxyvitamin D and the incidence of peripheral artery disease in the elderly: The Pro.V.A study

Nicola Veronese, Enzo Manzato, Francesco Bolzetta, Nicola Veronese, Marina De Rui, Stefania Maggi, Elena Debora Toffanello, Alessandra Coin, Egle Perissinotto, Sabina Zambon, Giuseppe Sergi, Giovannella Baggio, Maria Chiara Corti, Gaetano Crepaldi

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10 Citazioni (Scopus)


Aim: This study was conducted to examine whether low serum levels of 25-hydroxyvitamin D (250HD) are associated with a higher risk of incident peripheral artery disease (PAD) in a representative group of elderly people. Methods: We followed 1568 community-dwelling elderly participants without PAD at the baseline among a sample of 2097 initially eligible over a mean of 4.4 years as part of the Progetto Veneto Anziani (Pro.V.A.) study. The baseline serum 250HD levels were categorized as <24, 25-49, 50-74, >75 nmol/L, and incident PAD was defined as an ankle-brachial index below 0.9. Results: At the baseline, there were no differences in known risk factors for PAD (BMI), waist circumference, diabetes, cardiovascular diseases, smoking habits, total cholesterol or in the ankle-brachial index (ABI) between the groups with different serum 250HD levels (<24, 25-49, 50-74, > 75 nmol/L). During a 4.4-year follow-up, 371 subjects developed PAD. The group with serum 250HD levels >75 nmol/L was set as the reference group, and an adjusted Cox's regression analysis showed no association between low vitamin D levels and incident PAD during the follow-up: the hazard ratio ranged from 0.76 95%CI: 0.41-1.42 for participants with serum 250HD levels below 25 nmol/L to 1.32 95%CI: 0.72-2.39 for those with serum 250HD levels between 50-74 nmol/L (p for trend = 0.08). These results did not change when participants were stratified by several risk factors for PAD. Conclusions: Baseline hypovitaminosis D did not predict the onset of PAD over a 4.4-year follow-up in elderly people. © 2015, Japan Atherosclerosis Society. All rights reserved.
Lingua originaleEnglish
pagine (da-a)726-734
Numero di pagine9
RivistaJournal of Atherosclerosis and Thrombosis
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2705???
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