Seroprevalence of Norovirus Genogroup IV antibodies among humans, Italy, 2010–2011

Giovanni Giammanco, Simona De Grazia, Chiara Ceci, Federica Di Profio, Fulvio Marsilio, Elisabetta Di Felice, Karin Bok, Ivano Massirio, Vito Martella, Canio Buonavoglia, Kim Y. Green, Eleonora Lorusso, Barbara Di Martino

Risultato della ricerca: Articlepeer review

25 Citazioni (Scopus)


Noroviruses (NoVs) of genogroup IV (GIV) (Alphatron-like) cause infections in humans and in carnivorous animals such as dogs and cats. We screened an age-stratified collection of serum samples from 535 humans in Italy, using virus-like particles of genotypes GIV.1, circulating in humans, and GIV.2, identified in animals, in ELISA, in order to investigate the prevalence of GIV NoV-specific IgG antibodies. Antibodies specific for both genotypes were detected, ranging from a prevalence of 6.6% to 44.8% for GIV.1 and from 6.8% to 15.1% for GIV.2 among different age groups. These data are consistent with a higher prevalence of GIV.1 strains in the human population. Analysis of antibodies against GIV.2 suggests zoonotic transmission of animal NoVs, likely attributable to interaction between humans and domestic pets. This finding, and recent documentation of human transmission of NoVs to dogs, indicate the possibility of an evolutionary relationship between human and animal NoVs.
Lingua originaleEnglish
pagine (da-a)1867-1871
Numero di pagine5
RivistaEmerging Infectious Diseases
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2726???
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